Title:
PHARMACEUTICALS COMPRISING SHIKONINS AS ACTIVE CONSTITUENT
Document Type and Number:
WIPO Patent Application WO/2004/073699
Kind Code:
A1
Abstract:
Disclosed pharmaceuticals comprising shikonins or its salts , which are useful for curing and preventing microbial infection diseases, inflammation diseases, malignant tumor, hemorrhage and hemopathy, and immunoregulatory diseases.
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Inventors:
WANG FEIXIN (CN)
Application Number:
PCT/CN2003/000138
Publication Date:
September 02, 2004
Filing Date:
February 21, 2003
Export Citation:
Assignee:
BEIJING JBC CHINESE TRADITIONA (CN)
WANG FEIXIN (CN)
WANG FEIXIN (CN)
International Classes:
A61K31/122; A61P7/00; A61P31/00; C07C50/32; (IPC1-7): A61K31/122; A61P31/00; A61P7/00; C07C50/32
Foreign References:
| CN1253972A | 2000-05-24 | |||
| CN1117525A | 1996-02-28 |
Other References:
LIN, ZHIBIN ET AL.: "Study on anti-inflammatory action of chemical composition of shikonin", BEIJING YIXUEYUAN XUEBAO, vol. 12, no. 2, 1980, pages 101 - 105
YAMASAKI KATSUHIRO ET AL., SCREENING TEST OF CRUDE DRUG EXTRACT ON ANTI-HIV ACTIVITY, 1993
MIN BYUNG-SUN: "Inhibitory effects of quinones on RNase H activity associated with HIV-1 reverse transcriptase", PHYTOTHERAPY RESEARCH: PTR, vol. 16, no. 1, March 2002 (2002-03-01), pages S57 - S62, XP009083381, DOI: doi:10.1002/ptr.808
HONDA G: "Isolation of Deoxyshikonin, an Antidermatophytic Principle from Lithospermum Erythrorhizon Cell Cultures", JOURNAL OF NATURAL PRODUCTS, vol. 51, no. 1, 1988, pages 152 - 154, XP000672274, DOI: doi:10.1021/np50055a025
AFZAL M: "Shikonin Derivatives Part 1,7-13 VI.Chemical Investigations of Arnebia-Decumbens", AGRICULTURAL AND BIOLOGICAL CHEMISTRY, vol. 50, no. 6, 1986, pages 1651 - 1652
COULADOUROS E A: "Tetrahedron Letters", vol. 38, 13 October 1997, ELSEVIER, article "Asymmetric Synthesis of Alkannin and Shikonin", pages: 7263 - 7266
YAMASAKI KATSUHIRO ET AL., SCREENING TEST OF CRUDE DRUG EXTRACT ON ANTI-HIV ACTIVITY, 1993
MIN BYUNG-SUN: "Inhibitory effects of quinones on RNase H activity associated with HIV-1 reverse transcriptase", PHYTOTHERAPY RESEARCH: PTR, vol. 16, no. 1, March 2002 (2002-03-01), pages S57 - S62, XP009083381, DOI: doi:10.1002/ptr.808
HONDA G: "Isolation of Deoxyshikonin, an Antidermatophytic Principle from Lithospermum Erythrorhizon Cell Cultures", JOURNAL OF NATURAL PRODUCTS, vol. 51, no. 1, 1988, pages 152 - 154, XP000672274, DOI: doi:10.1021/np50055a025
AFZAL M: "Shikonin Derivatives Part 1,7-13 VI.Chemical Investigations of Arnebia-Decumbens", AGRICULTURAL AND BIOLOGICAL CHEMISTRY, vol. 50, no. 6, 1986, pages 1651 - 1652
COULADOUROS E A: "Tetrahedron Letters", vol. 38, 13 October 1997, ELSEVIER, article "Asymmetric Synthesis of Alkannin and Shikonin", pages: 7263 - 7266
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENT LTD. (8 Beijing, CN)
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