Title:
PHARMACOLOGICAL FORMULATION COMPRISING CYCLO (HIS-PRO) AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING DIABETES MELLITUS
Document Type and Number:
WIPO Patent Application WO/2019/124860
Kind Code:
A1
Abstract:
The present invention relates to a pharmacological formulation comprising cyclo(His-Pro) as an effective ingredient for preventing or treating diabetes mellitus. More particularly, the present invention exhibits the effect of lowering a glycated hemoglobin (HbA1c) level in blood and further alleviating leptin resistance. In addition, the present invention relates to a pharmacological formulation for prevention or treatment of diabetes mellitus, wherein the pharmacological formulation comprises cyclo(His-Pro) and zinc and is administered once a day.
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Inventors:
LEE HEON JONG (KR)
OLMSTEAD KAY (US)
SONG MOON KI (US)
KIM KYONG-TAI (KR)
LEE IN-KYU (KR)
JUNG HOE-YUNE (KR)
OLMSTEAD KAY (US)
SONG MOON KI (US)
KIM KYONG-TAI (KR)
LEE IN-KYU (KR)
JUNG HOE-YUNE (KR)
Application Number:
PCT/KR2018/015720
Publication Date:
June 27, 2019
Filing Date:
December 11, 2018
Export Citation:
Assignee:
NOVMETAPHARMA CO LTD (KR)
International Classes:
A61K31/4985; A61K9/00; A61K33/30; A61P3/10
Foreign References:
| KR20010022786A | 2001-03-26 | |||
| KR20090120202A | 2009-11-24 |
Other References:
SONG, M. K. ET AL.: "Metabolic relationship between diabetes and alzheimer's disease affected by Cyclo(His-Pro) plus zinc treatment", BBA CLINICAL, vol. 7, 2 October 2016 (2016-10-02) - 2017, pages 41 - 54, XP055620302
JUNG, E. Y. ET AL.: "Effects of Cyclo-His-Pro-enriched yeast hydrolysate on blood glucose levels and lipid metabolism in obese diabetic ob/ob mice", NUTRITION RESEARCH AND PRACTICE, vol. 10, no. 2, April 2016 (2016-04-01), pages 154 - 160, XP055620307
SONG, M. K.: "Synergistic antidiabetic activities of zinc, Cyclo (His-Pro), and arachidonic acid", METABOLISM, vol. 50, no. 1, 2001, pages 53 - 59, XP002649540, doi:10.1053/META.2001.19427
JUNG, E. Y. ET AL.: "Effects of Cyclo-His-Pro-enriched yeast hydrolysate on blood glucose levels and lipid metabolism in obese diabetic ob/ob mice", NUTRITION RESEARCH AND PRACTICE, vol. 10, no. 2, April 2016 (2016-04-01), pages 154 - 160, XP055620307
SONG, M. K.: "Synergistic antidiabetic activities of zinc, Cyclo (His-Pro), and arachidonic acid", METABOLISM, vol. 50, no. 1, 2001, pages 53 - 59, XP002649540, doi:10.1053/META.2001.19427
Attorney, Agent or Firm:
CHOI, Eun Sun (KR)
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