Title:
PHARMACOLOGY BIOASSAYS FOR DRUG DISCOVERY, TOXICITY EVALUATION AND IN VITRO CANCER RESEARCH USING A 3D NANO-CELLULOSE SCAFFOLD AND LIVING TISSUE
Document Type and Number:
WIPO Patent Application WO/2012/071578
Kind Code:
A3
Abstract:
The present invention relates to pharmacology bioassays used in drug discovery, drug screening and toxicity evaluations. More specifically, the present invention relates to novel systems and methods used for production and control of 3-D architecture and morphology of living tissues and organs produced by mammalian cells using 3D porous scaffolds based on nano- cellulose. The resultant nano-cellulose based structures are useful as tools in high throughput assays for drugs. More particularly, embodiments of the present invention relate to systems and methods for evaluating a drug that comprise a microtiter plate comprising a plurality of wells, each well comprising: a 3D non-biodegradable, inert, nano-cellulose scaffold; and optionally cells capable of forming living tissue or organs; and optionally a drug having a biological activity of interest; and optionally a detector capable of detecting the biological activity in a high throughput format.
Inventors:
GATENHOLM PAUL (US)
Application Number:
PCT/US2011/062157
Publication Date:
August 23, 2012
Filing Date:
November 25, 2011
Export Citation:
Assignee:
BC GENESIS LLC (US)
GATENHOLM PAUL (US)
GATENHOLM PAUL (US)
International Classes:
G01N33/15; A61L27/20; G01N33/50; B82Y40/00
Foreign References:
| US20080102478A1 | 2008-05-01 | |||
| US20060019326A1 | 2006-01-26 | |||
| US20060127368A1 | 2006-06-15 | |||
| US6143293A | 2000-11-07 | |||
| US20090286317A1 | 2009-11-19 |
Attorney, Agent or Firm:
MAYBERRY, Michele, L. (1750 Kraft Dr.Suite 220, Blacksburg VA, US)
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