Title:
PHASE CHANGING FORMULATIONS OF NUCLEIC ACID PAYLOADS
Document Type and Number:
WIPO Patent Application WO/2012/173994
Kind Code:
A3
Abstract:
The present invention is based, at least in part, upon discovery of a process for identifying phase changing peptides. Such phase changing peptides are capable of enhancing in vitro and in vivo delivery of oligonucleotides (e.g., dsRNAs) in lipidic, vesicular, micellar and/or naked oligonucleotide formulations.
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Inventors:
BROWN BOB DALE (US)
BASU SUJIT KUMAR (US)
BASU SUJIT KUMAR (US)
Application Number:
PCT/US2012/042057
Publication Date:
May 16, 2013
Filing Date:
June 12, 2012
Export Citation:
Assignee:
DICERNA PHARMACEUTICALS INC (US)
BROWN BOB DALE (US)
BASU SUJIT KUMAR (US)
BROWN BOB DALE (US)
BASU SUJIT KUMAR (US)
International Classes:
G01N33/68; C12N15/11; C12Q1/68
Domestic Patent References:
| WO2004020981A2 | 2004-03-11 | |||
| WO2000023113A1 | 2000-04-27 |
Other References:
HALLBRINK ET AL.: "Prediction of cell-penetrating peptides", INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, vol. 11, no. 4, December 2005 (2005-12-01), pages 249 - 259, XP002424462
PUJALS ET AL.: "Mechanistic aspects of CPP-mediated intracellular drug delivery: relevance of CPP self-assembly", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1758, no. 3, 30 January 2006 (2006-01-30), pages 264 - 279, XP005436028
PUJALS ET AL.: "Mechanistic aspects of CPP-mediated intracellular drug delivery: relevance of CPP self-assembly", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1758, no. 3, 30 January 2006 (2006-01-30), pages 264 - 279, XP005436028
Attorney, Agent or Firm:
WILLIAMS, Kathleen et al. (P.O. Box 55874Boston, MA, US)
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