Title:
PHENOL GROUP-MODIFIED DECELLULARIZED MUSCLE TISSUE-DERIVED EXTRACELLULAR MATRIX FOR MUSCLE REGENERATION, AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2023/136651
Kind Code:
A1
Abstract:
The present invention relates to a phenol-modified decellularized muscle tissue-derived extracellular matrix for muscle regeneration and a method for preparing same. The phenol group-modified decellularized muscle tissue-derived extracellular matrix of the present invention is characterized by containing components similar to original proteins of muscle tissue for muscle regeneration and forming a hydrogel having a stable porous nanofiber structure through dimerization crosslinking between phenol groups, wherein the hydrogel can effectively treat muscle injury or muscle diseases by being administered or implanted into muscle tissue without causing side effects such as an immune response or liver or kidney dysfunction.
Inventors:
CHO SEUNG WOO (KR)
CHOI SOO JEONG (KR)
LEE MI JEONG (KR)
CHOI YI SUN (KR)
AN SOO HWAN (KR)
CHOI SOO JEONG (KR)
LEE MI JEONG (KR)
CHOI YI SUN (KR)
AN SOO HWAN (KR)
Application Number:
PCT/KR2023/000638
Publication Date:
July 20, 2023
Filing Date:
January 13, 2023
Export Citation:
Assignee:
UNIV YONSEI IACF (KR)
International Classes:
C12N5/00; C12N5/077
Foreign References:
| KR20210103942A | 2021-08-24 | |||
| KR102308719B1 | 2021-10-06 | |||
| KR20190115036A | 2019-10-10 | |||
| KR20200068236A | 2020-06-15 |
Other References:
LEE HYEONGJIN; JU YOUNG MIN; KIM ICKHEE; ELSANGEEDY EBRAHIM; LEE JOON HO; YOO JAMES J.; ATALA ANTHONY; LEE SANG JIN: "A novel decellularized skeletal muscle-derived ECM scaffolding system for in situ muscle regeneration", METHODS, ACADEMIC PRESS, NL, vol. 171, 3 July 2019 (2019-07-03), NL , pages 77 - 85, XP085998158, ISSN: 1046-2023, DOI: 10.1016/j.ymeth.2019.06.027
Attorney, Agent or Firm:
PCR INTELLECTUAL PROPERTY LAW FIRM (KR)
Download PDF: