Title:
PHENOLIC ACID SALTS OF GABAPENTIN IN LIQUID AND/OR SEMI-SOLID DOSAGE FORMS AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO2004093867
Kind Code:
A3
Abstract:
The present invention relates to pharmaceutical compositions of gabapentin tannate, processes for production of those compositions and methods of use of those compositions. The present invention provides a novel process for preparation of the tannate salt of gabapentin in liquid or semi-solid dosage form for human and veterinary pharmaceutical use. Tannate salts of active pharmaceutical ingredients are used in sustained release applications and to improve certain organoleptic properties such as taste. The process may utilize either natural or synthetic tannic acid.
Inventors:
KIEL JEFFREY S (US)
THOMAS H GREG (US)
MANI NARASIMHAN (US)
THOMAS H GREG (US)
MANI NARASIMHAN (US)
Application Number:
PCT/US2004/007872
Publication Date:
December 02, 2004
Filing Date:
March 16, 2004
Export Citation:
Assignee:
KIEL LAB INC (US)
KIEL JEFFREY S (US)
THOMAS H GREG (US)
MANI NARASIMHAN (US)
KIEL JEFFREY S (US)
THOMAS H GREG (US)
MANI NARASIMHAN (US)
International Classes:
A61K31/7024; A61P25/00; C07H5/04; (IPC1-7): A61K31/195; C07C229/48; C07C61/08; A61P25/00
Foreign References:
| US4024175A | 1977-05-17 | |||
| US5663415A | 1997-09-02 | |||
| US20030077321A1 | 2003-04-24 |
Other References:
BERGE ET AL: "Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 66, no. 1, January 1977 (1977-01-01), pages 1 - 19, XP000562636
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