Title:
PHENOLIC COMPOUND PRODUCTION METHOD, AND MODIFIED ENZYME
Document Type and Number:
WIPO Patent Application WO/2024/024806
Kind Code:
A1
Abstract:
This phenolic compound production method is a method for producing a compound represented by formula (2) from a compound represented by formula (1), and comprises a step for bringing an enzyme into contact with the compound represented by formula (1), wherein the enzyme has an activity of cleaving the carbon-carbon double bond of the compound represented by formula (1) (excluding the case where the compound represented by formula (1) is ferulic acid and the enzyme is a protein having the amino acid sequence represented by SEQ ID NO: 1). In the formula, R1 represents a hydrogen atom or an alkyl group, R2 each independently represents an alkoxy group, a hydroxy group, an alkyl group or a halogen atom, and n is a number of 0-4.
Inventors:
FURUYA TOSHIKI (JP)
SAKAMOTO SATSUKI (JP)
FUJIMAKI SHIZUKA (JP)
SAKAMOTO SATSUKI (JP)
FUJIMAKI SHIZUKA (JP)
Application Number:
PCT/JP2023/027278
Publication Date:
February 01, 2024
Filing Date:
July 25, 2023
Export Citation:
Assignee:
UNIV TOKYO SCIENCE FOUND (JP)
International Classes:
C12N15/53; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/02; C12N9/04; C12N15/63; C12P7/22
Domestic Patent References:
| WO2020223417A1 | 2020-11-05 | |||
| WO2020223418A2 | 2020-11-05 |
Foreign References:
| CN108715826A | 2018-10-30 |
Other References:
NETHAJI J. GALLAGE, ESBEN H. HANSEN, RUBINI KANNANGARA, CARL ERIK OLSEN, MOHAMMED SADDIK MOTAWIA, KIRSTEN JøRGENSEN, INGER HO: "Vanillin formation from ferulic acid in Vanilla planifolia is catalysed by a single enzyme", NATURE COMMUNICATIONS, vol. 5, no. 1, 1 December 2014 (2014-12-01), XP055527961, DOI: 10.1038/ncomms5037
NI JUN, WU YU-TONG, TAO FEI, PENG YUAN, XU PING: "A Coenzyme-Free Biocatalyst for the Value-Added Utilization of Lignin-Derived Aromatics", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 140, no. 47, 28 November 2018 (2018-11-28), pages 16001 - 16005, XP093133542, ISSN: 0002-7863, DOI: 10.1021/jacs.8b08177
SATSUKI SAKAMOTO, KUNIKI KINO, TOSHIKI FURUYA: "3A03-05 Mutagenesis of a C=C bond cleavage oxygenase and its use in vanillin synthesis", THE 74TH CONGRESS OF THE JAPANESE SOCIETY OF BIOTECHNOLOGY COLLECTION OF KEYNOTE SPEECHES, 3 October 2022 (2022-10-03), pages 152, XP093133549, Retrieved from the Internet [retrieved on 20240221]
NI JUN, WU YU-TONG, TAO FEI, PENG YUAN, XU PING: "A Coenzyme-Free Biocatalyst for the Value-Added Utilization of Lignin-Derived Aromatics", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 140, no. 47, 28 November 2018 (2018-11-28), pages 16001 - 16005, XP093133542, ISSN: 0002-7863, DOI: 10.1021/jacs.8b08177
SATSUKI SAKAMOTO, KUNIKI KINO, TOSHIKI FURUYA: "3A03-05 Mutagenesis of a C=C bond cleavage oxygenase and its use in vanillin synthesis", THE 74TH CONGRESS OF THE JAPANESE SOCIETY OF BIOTECHNOLOGY COLLECTION OF KEYNOTE SPEECHES, 3 October 2022 (2022-10-03), pages 152, XP093133549, Retrieved from the Internet
Attorney, Agent or Firm:
TAIYO, NAKAJIMA & KATO (JP)
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