Title:
PHENOTHIAZINE FERROPTOSIS INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/098715
Kind Code:
A1
Abstract:
A phenothiazine ferroptosis inhibitor, a preparation method therefor and an application thereof. Specifically provided is a compound represented by formula I, or a salt thereof, or a stereoisomer thereof. The synthesized phenothiazine compound has a good inhibitory effect on ferroptosis and has good drug safety. Moreover, the compound can be used to prepare a ferroptosis inhibitor, and can also be used to prepare a drug for treating diseases related to ferroptosis, such as neurodegenerative diseases, tumors, tissue ischemia reperfusion injury, stroke, cardiovascular diseases, renal failure, and diabetic complications.
Inventors:
YANG SHENGYONG (CN)
LI LINLI (CN)
LI LINLI (CN)
Application Number:
PCT/CN2020/129707
Publication Date:
May 27, 2021
Filing Date:
November 18, 2020
Export Citation:
Assignee:
CHENGDU HENGHAO INVEST CO LTD (CN)
International Classes:
C07D279/20; A61K31/5415; A61P9/10; A61P25/16; A61P25/28; A61P35/00; A61P39/06; C07D417/06; C07D417/10
Foreign References:
| CN109796424A | 2019-05-24 | |||
| CN108484527A | 2018-09-04 | |||
| CN109748884A | 2019-05-14 | |||
| CN1131944A | 1996-09-25 |
Other References:
KIM KI-SUK, KIM EUN-JOO: "The Phenothiazine Drugs Inhibit hERG Potassium Channels", DRUG AND CHEMICAL TOXICOLOGY., vol. 28, no. 3, 31 December 2005 (2005-12-31), US, pages 303 - 313, XP009528169, ISSN: 0148-0545, DOI: 10.1081/dct-200064482
KEYNES ROBERT G.: "N10-carbonyl-substituted phenothiazines inhibiting lipid peroxidation and associated nitric oxide consumption powerfully protect brain tissue against oxidative stress;", CHEMICAL BIOLOGY & DRUG DESIGN, vol. 94, 25 May 2019 (2019-05-25), pages 1680 - 1693, XP055814010
KEYNES ROBERT G.: "N10-carbonyl-substituted phenothiazines inhibiting lipid peroxidation and associated nitric oxide consumption powerfully protect brain tissue against oxidative stress;", CHEMICAL BIOLOGY & DRUG DESIGN, vol. 94, 25 May 2019 (2019-05-25), pages 1680 - 1693, XP055814010
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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