Title:
PHENOXYALKYLAMINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2014/112646
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a compound having a selective inhibitory activity on LAT-1 that can be expressed in a tumor cell at a high level. The present invention provides: a compound represented by formula (I) [wherein each symbol is as defined in the description] or a salt thereof; and a LAT-1 inhibitor comprising the compound or the salt.
Inventors:
KANAI YOSHIKATSU (JP)
NAGAMORI SHUSHI (JP)
KITAURA YOSHIHIKO (JP)
NEYA MASAHIRO (JP)
MATSUSHITA NAOHIRO (JP)
NAGAMORI SHUSHI (JP)
KITAURA YOSHIHIKO (JP)
NEYA MASAHIRO (JP)
MATSUSHITA NAOHIRO (JP)
Application Number:
PCT/JP2014/051144
Publication Date:
July 24, 2014
Filing Date:
January 21, 2014
Export Citation:
Assignee:
UNIV OSAKA (JP)
KNC LAB CO LTD (JP)
KNC LAB CO LTD (JP)
International Classes:
C07C211/09; A61K31/138; A61K31/341; A61K31/381; A61K31/40; A61K31/421; A61K31/426; A61K31/4409; A61K31/4453; A61K31/47; A61K31/4704; A61P35/00; A61P43/00; C07C217/04; C07C217/72; C07C255/37; C07C255/54; C07C271/16; C07C271/20; C07C317/22; C07C317/28; C07C323/20; C07C323/25; C07D209/48; C07D213/68; C07D215/22; C07D263/32; C07D277/28; C07D295/08; C07D307/52; C07D333/20; C07D401/12; C07D403/12; C07D405/04; C07D409/04; C07D413/04; C07D417/04
Domestic Patent References:
| WO2003066574A1 | 2003-08-14 | |||
| WO2008081537A1 | 2008-07-10 | |||
| WO2001062713A1 | 2001-08-30 | |||
| WO2007095756A1 | 2007-08-30 |
Foreign References:
| JP2008501707A | 2008-01-24 | |||
| JP2007537291A | 2007-12-20 | |||
| JP2004536104A | 2004-12-02 | |||
| JP2987643B2 | 1999-12-06 | |||
| JPH07179422A | 1995-07-18 |
Other References:
LA REGINA, G. ET AL.: "1-[(3-Aryloxy-3-aryl) propyl]-lH-imidazoles, New Imidazoles with Potent Activity against Candida albicans and Dermatophytes. Synthesis, Structure-Activity Relationship, and Molecular Modeling Studies", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, no. 13, 2008, pages 3841 - 3855, XP055269706
BERGER, D. ET AL.: "Novel Multidrug Resistance Reversal Agents", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 12, 1999, pages 2145 - 2161, XP055269710
BARLUENGA, J. ET AL.: "Alkaline sodium borohydride-promoted reductive alkylation of beta-aminomercurials. Synthesis of 1,5-functionalized amines", SYNTHESIS, vol. 12, 1985, pages 1125 - 1129, XP055269718
KUMAR, R. ET AL.: "Enantioselective Alkylation of Aldehydes Using Functionalized Alkylboron Reagents Catalyzed by a Chiral Titanium Complex", ORGANIC LETTERS, vol. 15, no. 16, 29 July 2013 (2013-07-29), pages 4198 - 4201, XP055269725
PHYSIOL. REV., vol. 70, 1990, pages 43 - 77
J. BIOL. CHEM., vol. 273, 1998, pages 23629 - 23632
BIOCHIM. BIOPHYS. ACTA, vol. 1514, 2001, pages 291 - 302
CANCER RES., vol. 55, 1995, pages 1152 - 1159
CANCER SCI., vol. 99, 2008, pages 2380 - 2386
BR. J. CANCER, vol. 98, 2008, pages 742 - 748
PATHOL. INT., vol. 59, 2009, pages 7 - 18
PATHOL. INT., vol. 61, 2011, pages 281 - 289
INT. J. CANCER, vol. 119, 2006, pages 484 - 492
J NUCL MED., vol. 44, 2003, pages 244 - 246
CLIN CANCER RES., vol. 13, 2007, pages 6369 - 6378
INT. J. CANCER, vol. 124, 2009, pages 1152 - 1160
CANCER LETT., vol. 276, 2009, pages 95 - 101
CANCER SCI., vol. 101, 2010, pages 173 - 179
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis, 3rd Edition", 1999, WILEY-INTERSCIENCE
SAWA, JUN WU; TAKAAKI AKAIKE; HIROSHI MAEDA, CANCER RESEARCH, vol. 60, 2000, pages 666 - 671
See also references of EP 2947066A4
BERGER, D. ET AL.: "Novel Multidrug Resistance Reversal Agents", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 12, 1999, pages 2145 - 2161, XP055269710
BARLUENGA, J. ET AL.: "Alkaline sodium borohydride-promoted reductive alkylation of beta-aminomercurials. Synthesis of 1,5-functionalized amines", SYNTHESIS, vol. 12, 1985, pages 1125 - 1129, XP055269718
KUMAR, R. ET AL.: "Enantioselective Alkylation of Aldehydes Using Functionalized Alkylboron Reagents Catalyzed by a Chiral Titanium Complex", ORGANIC LETTERS, vol. 15, no. 16, 29 July 2013 (2013-07-29), pages 4198 - 4201, XP055269725
PHYSIOL. REV., vol. 70, 1990, pages 43 - 77
J. BIOL. CHEM., vol. 273, 1998, pages 23629 - 23632
BIOCHIM. BIOPHYS. ACTA, vol. 1514, 2001, pages 291 - 302
CANCER RES., vol. 55, 1995, pages 1152 - 1159
CANCER SCI., vol. 99, 2008, pages 2380 - 2386
BR. J. CANCER, vol. 98, 2008, pages 742 - 748
PATHOL. INT., vol. 59, 2009, pages 7 - 18
PATHOL. INT., vol. 61, 2011, pages 281 - 289
INT. J. CANCER, vol. 119, 2006, pages 484 - 492
J NUCL MED., vol. 44, 2003, pages 244 - 246
CLIN CANCER RES., vol. 13, 2007, pages 6369 - 6378
INT. J. CANCER, vol. 124, 2009, pages 1152 - 1160
CANCER LETT., vol. 276, 2009, pages 95 - 101
CANCER SCI., vol. 101, 2010, pages 173 - 179
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis, 3rd Edition", 1999, WILEY-INTERSCIENCE
SAWA, JUN WU; TAKAAKI AKAIKE; HIROSHI MAEDA, CANCER RESEARCH, vol. 60, 2000, pages 666 - 671
See also references of EP 2947066A4
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
Download PDF:
Previous Patent: MOVEMENT INFORMATION DISPLAY DEVICE AND PROGRAM
Next Patent: INFORMATION PROCESSING DEVICE
Next Patent: INFORMATION PROCESSING DEVICE