Title:
PHENYL AMIDE COMPOUNDS AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2023/245015
Kind Code:
A3
Abstract:
The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for inhibiting certain protein-protein interactions, and for treating cancer.
Inventors:
HOUANG EVELYNE (US)
KONST ZEF (US)
LEFFLER ABBA (US)
LEVINSON ADAM (US)
PLACZEK ANDREW (US)
RUVINSKY ANATOLY (US)
GREENWOOD JEREMY
KONST ZEF (US)
LEFFLER ABBA (US)
LEVINSON ADAM (US)
PLACZEK ANDREW (US)
RUVINSKY ANATOLY (US)
GREENWOOD JEREMY
Application Number:
PCT/US2023/068371
Publication Date:
February 08, 2024
Filing Date:
June 13, 2023
Export Citation:
Assignee:
SCHROEDINGER INC (US)
International Classes:
A61K31/015; C07C235/42; C07C235/58; C07C235/44
Foreign References:
| US10188649B2 | 2019-01-29 |
Other References:
DATABASE PubChem Substance ANONYMOUS : "AKOS006094985 ", XP093138523, retrieved from PubChem
PARK SUN YOU; OH YONG JIN; LHO YUNMEE; JEONG JU HUI; LIU KWANG-HYEON; SONG JAEYOUNG; KIM SOONG-HYUN; HA EUNYOUNG; SEO YOUNG HO: "Design, synthesis, and biological evaluation of a series of resorcinol-basedN-benzyl benzamide derivatives as potent Hsp90 inhibitors", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 143, 21 November 2017 (2017-11-21), AMSTERDAM, NL , pages 390 - 401, XP085306064, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2017.11.054
ZHU HUAJIAN, LI WENLONG, SHUAI WEN, LIU YANG, YANG LIMEI, TAN YUCHEN, ZHENG TIANDONG, YAO HONG, XU JINYI, ZHU ZHEYING, YANG DONG-H: "Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 216, 1 April 2021 (2021-04-01), AMSTERDAM, NL , pages 113316, XP093138499, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2021.113316
PARK SUN YOU; OH YONG JIN; LHO YUNMEE; JEONG JU HUI; LIU KWANG-HYEON; SONG JAEYOUNG; KIM SOONG-HYUN; HA EUNYOUNG; SEO YOUNG HO: "Design, synthesis, and biological evaluation of a series of resorcinol-basedN-benzyl benzamide derivatives as potent Hsp90 inhibitors", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 143, 21 November 2017 (2017-11-21), AMSTERDAM, NL , pages 390 - 401, XP085306064, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2017.11.054
ZHU HUAJIAN, LI WENLONG, SHUAI WEN, LIU YANG, YANG LIMEI, TAN YUCHEN, ZHENG TIANDONG, YAO HONG, XU JINYI, ZHU ZHEYING, YANG DONG-H: "Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 216, 1 April 2021 (2021-04-01), AMSTERDAM, NL , pages 113316, XP093138499, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2021.113316
Attorney, Agent or Firm:
PINO, Mark et al. (US)
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