PHENYLCARBOXYLIC ACID DERIVATIVES - OTSUKA PHARMA CO LTD

Title:

PHENYLCARBOXYLIC ACID DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/1989/003819

Kind Code:

A1

Abstract:

Phenylcarboxylic acid derivatives represented by formula (I), and their salts, wherein R1 and R2 each represents H, halogen, alkyl, haloalkyl, alkanoyl, cycloalkyl, nitro, amino, -O-D-R5 (wherein D represents alkylene, and R5 represents H, amino, morpholino, carboxyl, phthalimido, phenyl or epoxy), substituted or unsubstituted phenoxy, substituted or unsubstituted phenylalkylamino, carboxylalkenyl or, when taken together, represent alkylenedioxy; R3 represents H, -E-R6 (wherein E represents alkylene, and R6 represents H, carboxyl, cyano, OH, phenylalkoxy or halogen-substituted phenyl or phenylcarbamoyl), -CO-G-R7 (wherein G represents alkylene, and R7 represents H or substituted or unsubstituted phenylcarbamoyl), substituted or unsubstituted benzoyl, alkenyl, carbamoyl, phenyl or halophenyl; R4 represents H, alkyl; A represents alkylene, cycloalkyl ring-fuzed alkylene or alkenylene; B represents alkylene or alkenylene; and $(1,3)$ represents 0 or 1. These compounds have an activity of inhibiting synthesis of fatty acids and cholesterol, and are useful for treating hyperlipemia, arteriosclerosis, obesity and diabetes.

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Inventors:

FUJII SETSURO (JP)
KAWAMURA HIROYUKI (JP)
WATANABE SHINICHI (JP)

Application Number:

PCT/JP1988/001065

Publication Date:

May 05, 1989

Filing Date:

October 20, 1988

Export Citation:

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Assignee:

OTSUKA PHARMA CO LTD (JP)

International Classes:

C07C217/22; C07C217/44; C07C217/46; C07C217/84; C07C217/86; C07C217/90; C07C225/22; C07C229/18; C07C233/17; C07C233/18; C07C233/69; C07C233/78; C07C255/25; C07C275/30; C07D295/092; C07D303/22; C07D317/58; C07D319/18; (IPC1-7): C07C93/06; A61K31/19; A61K31/215; A61K31/275; A61K31/335; A61K31/40; A61K31/535; C07C93/10; C07C93/12; C07C97/10; C07C101/16; C07C101/453; C07C103/38; C07C103/44; C07C103/78; C07C103/82; C07C121/43; C07D209/48; C07D295/08; C07D303/20

Other References:

CHEMICAL ABSTRACTS, Vol. 93, No. 19, 10 November 1980 (10. 11. 80) (Columbus, Ohio, U.S.A.), page 620, Abstract No. 185904j, N.Kh. MAKSUDOV et. al., "O-Alkylation of Hydroxybenzoic Acids" U2b. Khim. Zh., 1980 (2), 46-50 (Russ)
See also references of EP 0394440A1

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