Title:
PHENYLPROPANOID SACCHARIDE ESTERS, METHODS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/183442
Kind Code:
A3
Abstract:
The present disclosure relates to phenylpropanoid saccharide esters, methods for the synthesis of libraries of phenylpropanoid saccharide esters with different degree and place of substitution in the sugar core, and their use as antimicrobial agents, cytotoxic agents and/or antitumoral agents. The present disclosure relates to a compound for formula I wherein R1, R2, R3 and R4 are independently selected from each other; R1 is selected from H or COCH3, R2, R3 and R4 is selected from H, OCH3, OH, for use in a method for the treatment of a microbial infection, or for use in a method for the treatment of a fungal infection or for use in a method for the treatment of cancer.
Inventors:
MARKOVA-PETROVA KRASIMIRA TODOROVA (PT)
FERNANDES RODRIGUES FERREIRA ISABEL CRISTINA (PT)
COSTA CALHELHA MANUEL RICARDO (PT)
SOKOVIC MARINA (RU)
FERNANDES RODRIGUES FERREIRA ISABEL CRISTINA (PT)
COSTA CALHELHA MANUEL RICARDO (PT)
SOKOVIC MARINA (RU)
Application Number:
PCT/IB2020/052378
Publication Date:
October 22, 2020
Filing Date:
March 16, 2020
Export Citation:
Assignee:
UNIV NOVA DE LISBOA (PT)
INST POLITECNICO DE BRAGANCA (PT)
INSTITUTE FOR BIOLOGICAL RES SINISA STANKOVIC (RU)
INST POLITECNICO DE BRAGANCA (PT)
INSTITUTE FOR BIOLOGICAL RES SINISA STANKOVIC (RU)
International Classes:
C07H13/04; A61K31/7024; A61K31/7028; A61P31/00; A61P31/04; A61P31/10; A61P33/00; A61P35/00; C07H13/08; C07H15/04
Foreign References:
| JPH07179348A | 1995-07-18 |
Other References:
P. PANDA ET AL: "Phenylpropanoid Sucrose Esters: Plant-Derived Natural Products as Potential Leads for New Therapeutics", CURRENT MEDICINAL CHEMISTRY, vol. 18, no. 21, 1 July 2011 (2011-07-01), NL, pages 3234 - 3251, XP055713705, ISSN: 0929-8673, DOI: 10.2174/092986711796391589
YONG-CHENG YANG ET AL: "Phytochemical and antitumor studies on Cynanchum mongolicum (Maxim.) Kom", NATURAL PRODUCT RESEARCH, 5 March 2019 (2019-03-05), GB, pages 1 - 7, XP055712122, ISSN: 1478-6419, DOI: 10.1080/14786419.2019.1574787
BIN LIU ET AL: "A Pair of New Non-glycosidic Iridoid Epimers from Scrophularia ningpoensis", HETEROCYCLES, vol. 96, no. 11, 1 January 2018 (2018-01-01), JP, pages 1991, XP055712124, ISSN: 0385-5414, DOI: 10.3987/COM-18-13991
SU TIAN ET AL: "Analysis of Phenolic Compounds in White Rice, Brown Rice, and Germinated Brown Rice", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 52, no. 15, 1 July 2004 (2004-07-01), US, pages 4808 - 4813, XP055570354, ISSN: 0021-8561, DOI: 10.1021/jf049446f
XIAO SHEN ET AL: "Effects of Scrophularia ningpoensis Hemsl. on Inhibition of Proliferation, Apoptosis Induction and NF-[kappa]B Signaling of Immortalized and Cancer Cell Lines", PHARMACEUTICALS, vol. 5, no. 2, 14 February 2012 (2012-02-14), pages 189 - 208, XP055625508, DOI: 10.3390/ph5020189
YONG-CHENG YANG ET AL: "Phytochemical and antitumor studies on Cynanchum mongolicum (Maxim.) Kom", NATURAL PRODUCT RESEARCH, 5 March 2019 (2019-03-05), GB, pages 1 - 7, XP055712122, ISSN: 1478-6419, DOI: 10.1080/14786419.2019.1574787
BIN LIU ET AL: "A Pair of New Non-glycosidic Iridoid Epimers from Scrophularia ningpoensis", HETEROCYCLES, vol. 96, no. 11, 1 January 2018 (2018-01-01), JP, pages 1991, XP055712124, ISSN: 0385-5414, DOI: 10.3987/COM-18-13991
SU TIAN ET AL: "Analysis of Phenolic Compounds in White Rice, Brown Rice, and Germinated Brown Rice", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 52, no. 15, 1 July 2004 (2004-07-01), US, pages 4808 - 4813, XP055570354, ISSN: 0021-8561, DOI: 10.1021/jf049446f
XIAO SHEN ET AL: "Effects of Scrophularia ningpoensis Hemsl. on Inhibition of Proliferation, Apoptosis Induction and NF-[kappa]B Signaling of Immortalized and Cancer Cell Lines", PHARMACEUTICALS, vol. 5, no. 2, 14 February 2012 (2012-02-14), pages 189 - 208, XP055625508, DOI: 10.3390/ph5020189
Attorney, Agent or Firm:
PATENTREE (PT)
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