Title:
PHENYLSULFONAMIDE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1997/045402
Kind Code:
A1
Abstract:
Phenylsulfonylamide derivatives represented by general formula (I) and salts thereof, (wherein R1 is hydrogen or alkyl; R2 is COOR3 or CONHOR4; E is vinylene or ethylene; A is hydrogen, alkyl, carbocycle or heterocycle; J is single bond or alkylene; R9 and R10 are each hydrogen, (substituted) alkyl, COR11, carbocycle, heterocycle, etc.; and R20 is hydrogen, (substituted) alkyl, etc.); processes for producing the same; a matrix metalloproteinase inhibitor containing the same; and medicines containing the same and serving as preventives and/or remedies for rheumatism, osteoarthritis, pathologic bone resorption, osteoporosis, periodontosis, interstitial nephritis, arteriosclerosis, pulmonary emphysema, hepatocirrhosis, corneal injury, diseases due to cancer cell metastasis, infiltration and proliferation, autoimmune diseases (such as Crohn's disease and Sjoegren's disease), diseases due to leukocyte emigration or infiltration, and neovascularization.
Inventors:
TAKAHASHI KANJI (JP)
SUGIURA TSUNEYUKI (JP)
SUGIURA TSUNEYUKI (JP)
Application Number:
PCT/JP1997/001735
Publication Date:
December 04, 1997
Filing Date:
May 23, 1997
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
TAKAHASHI KANJI (JP)
SUGIURA TSUNEYUKI (JP)
TAKAHASHI KANJI (JP)
SUGIURA TSUNEYUKI (JP)
International Classes:
C07D295/14; A61K31/18; A61K31/195; A61K31/198; A61K31/215; A61K31/38; A61K31/381; A61K31/40; A61K31/403; A61K31/404; A61K31/405; A61K31/415; A61K31/44; A61K31/4402; A61K31/535; A61K31/5375; A61P1/02; A61P1/16; A61P9/00; A61P9/10; A61P11/00; A61P27/02; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07C303/40; C07C311/00; C07C311/16; C07C311/19; C07C311/29; C07C311/37; C07C311/53; C07D207/16; C07D209/20; C07D213/34; C07D213/36; C07D213/42; C07D213/52; C07D233/56; C07D233/60; C07D233/61; C07D333/08; C07D403/12; C07D521/00; (IPC1-7): C07C311/00; A61K31/18; A61K31/195; A61K31/215; A61K31/40; A61K31/405; A61K31/415; A61K31/44; A61K31/535; C07D207/16; C07D209/20; C07D213/40; C07D213/52; C07D233/56; C07D295/13; C07D403/12
Foreign References:
| JPS62181296A | 1987-08-08 | |||
| JPH06256293A | 1994-09-13 |
Other References:
TETRAHEDRON: ASYMMETRY, (1995), Vol. 6, No. 10, K. KAMAHORI et al., "Synthesis of Polymer-Supported Chiral N-Sulfonylamino Acids and Their Use in Asymmetric Diels-Alder Reaction of Cyclopentadiene with Methacrolein", pages 2547-2555.
EUR. POLYM. J., (1992), Vol. 28, No. 10, V. BERTINI et al., "Synthesis of Functionalized Benzenesulfonyl Monomers, Polymers and Copolymers Designed for the Selective Flocculation of Aqueous Smithonite Dispersions", pages 1225-1229.
BIOMATERIALS, (1988), Vol. 9, No. 5, E. DULOS et al., "Adsorption of Plasma Proteins Onto Anticoagulant Polystyrene Derivatives: a Fluorescence Study", pages 405-412.
COLLOIDS AND SURFACES, (1985), Vol. 16, No. 3-4, N. DEBAILLOU et al., "Adsorption of Human Albumin and Fibrinogen Onto Heparin-Like Materials", pages 271-288.
See also references of EP 0915086A4
EUR. POLYM. J., (1992), Vol. 28, No. 10, V. BERTINI et al., "Synthesis of Functionalized Benzenesulfonyl Monomers, Polymers and Copolymers Designed for the Selective Flocculation of Aqueous Smithonite Dispersions", pages 1225-1229.
BIOMATERIALS, (1988), Vol. 9, No. 5, E. DULOS et al., "Adsorption of Plasma Proteins Onto Anticoagulant Polystyrene Derivatives: a Fluorescence Study", pages 405-412.
COLLOIDS AND SURFACES, (1985), Vol. 16, No. 3-4, N. DEBAILLOU et al., "Adsorption of Human Albumin and Fibrinogen Onto Heparin-Like Materials", pages 271-288.
See also references of EP 0915086A4
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