Title:
PHLORETIN-ISONIAZID COCRYSTAL AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2024/037138
Kind Code:
A1
Abstract:
The present invention relates to the field of pharmaceutic preparations, and in particular, to a phloretin-isoniazid cocrystal and a preparation method therefor. The phloretin-isoniazid cocrystal of the present invention is a cocrystal of phloretin and isoniazid, wherein a stoichiometric ratio of phloretin to isoniazid is 1:1. The preparation method for the phloretin-isoniazid cocrystal comprises the following steps: weighing phloretin and isoniazid in proportion, adding the phloretin and the isoniazid into a solvent, stirring until the phloretin and the isoniazid are completely dissolved, uniformly mixing for 12-15 h at 300-400 r/min, slowly evaporating the mixed solution at room temperature after the uniform mixing, completely volatilizing the solvent after 3-5 days to obtain a large number of crystals, and drying the crystals to obtain the cocrystal. Compared with phloretin and a phloretin-isoniazid mixture, the equilibrium solubility and the dissolution rate of the phloretin-isoniazid cocrystal in the present invention in an environment with pH values of 1.2 and 6.8 are obviously improved.
Inventors:
CHEN HANKUN (CN)
LU ZHONGYU (CN)
WANG ENHAN (CN)
LIN HONGJIA (CN)
LU ZHONGYU (CN)
WANG ENHAN (CN)
LIN HONGJIA (CN)
Application Number:
PCT/CN2023/098925
Publication Date:
February 22, 2024
Filing Date:
June 07, 2023
Export Citation:
Assignee:
GUANGZHOU QINGLAN BIOTECHNOLOGY CO LTD (CN)
International Classes:
A61K31/12; C07C49/83; A61P3/10; A61P17/00; A61P37/00; A61P37/06; A61P39/06; C07C45/81; C07D213/86
Foreign References:
| CN115304468A | 2022-11-08 | |||
| CN105362229A | 2016-03-02 | |||
| CN102166193A | 2011-08-31 | |||
| CN104817526A | 2015-08-05 | |||
| CN105669543A | 2016-06-15 | |||
| CN107522655A | 2017-12-29 |
Attorney, Agent or Firm:
SBZL IP LAW OFFICE (CN)
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