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Title:
PHOSPHATE OF TOLL-LIKE RECEPTOR INHIBITING COMPOUND AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/193831
Kind Code:
A1
Abstract:
The present invention relates to the technical field of pharmaceutical salt forms, and specifically relates to a phosphate of a toll-like receptor inhibiting compound and a preparation method therefor. In the phosphate of the toll-like receptor inhibiting compound, the toll-like receptor inhibiting compound has a chemical structural formula as represented by (I). The phosphate of the toll-like receptor inhibiting compound has properties such as high thermostability, good high-humidity stability, high solid state stability, high crystallinity, higher solubility, and lower hygroscopicity; the present invention provides more possible research avenues for the research, development, and production of specific pharmaceutical formulations of toll-like receptor inhibiting compounds, and facilitates the research, development, and industrial production of specific pharmaceutical preparations of toll-like receptor inhibiting compounds.

Inventors:
GAO MENG (CN)
DING DONG (CN)
Application Number:
PCT/CN2023/098479
Publication Date:
October 12, 2023
Filing Date:
June 06, 2023
Export Citation:
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Assignee:
TOLL BIOTECH CO LTD BEIJING (CN)
International Classes:
C07D215/20; A61K31/47; A61P37/02; A61P43/00
Foreign References:
CN114426518A2022-05-03
CN111542515A2020-08-14
Other References:
ZHANG, SHUTING ET AL.: "Small-Molecule Inhibition of TLR8 Through Stabilization of Its Resting State", NATURE CHEMICAL BIOLOGY, vol. 14, no. 1, 20 November 2017 (2017-11-20), XP037115641, ISSN: 1552-4450, DOI: 10.1038/nchembio.2518
HU, ZHENYI ET AL.: "Small-Molecule TLR8 Antagonists via Structure-Based Rational Design", CELL CHEMICAL BIOLOGY, vol. 25, no. 10, 9 August 2018 (2018-08-09), XP085531594, ISSN: 2451-9448, DOI: 10.1016/j.chembiol.2018.07.004
Attorney, Agent or Firm:
MERITS & TREE (CN)
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