Title:
PHOSPHONYL DERIVATIVE, AND COMPOSITION AND PHARMACEUTICAL APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/228547
Kind Code:
A1
Abstract:
Provided are the compound shown in general formula (I) or a stereoisomer, a deuterated compound, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt, or co-crystal thereof, an intermediate thereof, and a use thereof in EGFR-related diseases such as cancer. B-L-K (I)
Inventors:
ZHANG CHEN (CN)
WANG JIANMIN (CN)
ZHAO CHENFEI (CN)
QIAN GUOFEI (CN)
MA JUNJIE (CN)
HUANG ZHENGGANG (CN)
YUAN SHUAI (CN)
HUANG ANBANG (CN)
ZHENG SHAOLONG (CN)
LI KAI (CN)
YU YAN (CN)
YE FEI (CN)
TANG PINGMING (CN)
LI YAO (CN)
NI JIA (CN)
YAN PANGKE (CN)
WANG JIANMIN (CN)
ZHAO CHENFEI (CN)
QIAN GUOFEI (CN)
MA JUNJIE (CN)
HUANG ZHENGGANG (CN)
YUAN SHUAI (CN)
HUANG ANBANG (CN)
ZHENG SHAOLONG (CN)
LI KAI (CN)
YU YAN (CN)
YE FEI (CN)
TANG PINGMING (CN)
LI YAO (CN)
NI JIA (CN)
YAN PANGKE (CN)
Application Number:
PCT/CN2022/090243
Publication Date:
November 03, 2022
Filing Date:
April 29, 2022
Export Citation:
Assignee:
SICHUAN HAISCO PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D401/14; A61K31/506; A61K31/675; A61P35/00; C07F9/53
Domestic Patent References:
| WO2021036922A1 | 2021-03-04 | |||
| WO2022012622A1 | 2022-01-20 | |||
| WO2022012623A1 | 2022-01-20 | |||
| WO2021173677A1 | 2021-09-02 | |||
| WO2020147838A1 | 2020-07-23 |
Foreign References:
| CN109912655A | 2019-06-21 | |||
| CN112079866A | 2020-12-15 | |||
| CN110357889A | 2019-10-22 | |||
| CN111285849A | 2020-06-16 |
Other References:
REN CHAOWEI, SUN NING, LIU HAIXIA, KONG YING, SUN RENHONG, QIU XING, CHEN JINJU, LI YAN, ZHANG JIANSHUI, ZHOU YUEDONG, ZHONG HUI, : "Discovery of a Brigatinib Degrader SIAIS164018 with Destroying Metastasis-Related Oncoproteins and a Reshuffling Kinome Profile", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 64, no. 13, 8 July 2021 (2021-07-08), US , pages 9152 - 9165, XP055981658, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.1c00373
NAT. REV. CANCER, vol. 7, 2007, pages 169 - 181
EXPERT OPIN. THER. TARGETS, vol. 16, 2012, pages 15 - 31
CELLS, vol. 8, 2019, pages 350 - 361
ACS CHEM. BIOL., vol. 12, 2017, pages 892 - 898
DRUG DISCOVERY TODAY TECHNOL., vol. 31, 2019, pages 15 - 27
NAT. REV. CANCER, vol. 7, 2007, pages 169 - 181
EXPERT OPIN. THER. TARGETS, vol. 16, 2012, pages 15 - 31
CELLS, vol. 8, 2019, pages 350 - 361
ACS CHEM. BIOL., vol. 12, 2017, pages 892 - 898
DRUG DISCOVERY TODAY TECHNOL., vol. 31, 2019, pages 15 - 27
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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