Title:
PHOTOCLEAVABLE PRODRUG-BASED NANOMEDICINE FOR IN-SITU MONITORABLE CANCER THERAPY
Document Type and Number:
WIPO Patent Application WO/2023/066076
Kind Code:
A1
Abstract:
The subject invention pertains to photocleavable prodrugs that facilitate the controllable drug delivery to the target sites modulated by light irradiation, including a photocleavable boron-dipyrromethene-derived prodrug and a dye, which achieved both high prodrug loading capacity (～99%) and efficient light-triggered prodrug activation. The incorporation of the dye not only stabilized the nanoparticles and contributed tumor targeting as usual, but also exhibited degradation after light irradiation and in-situ monitoring of nanoparticle dissociation by fluorescent imaging.
Inventors:
WANG WEIPING (CN)
LONG KAIQI (CN)
WANG YIFAN (CN)
LONG KAIQI (CN)
WANG YIFAN (CN)
Application Number:
PCT/CN2022/124524
Publication Date:
April 27, 2023
Filing Date:
October 11, 2022
Export Citation:
Assignee:
UNIV HONG KONG (CN)
International Classes:
A61K41/00; A61K31/196; A61K47/20; A61P35/00
Foreign References:
| CN112566663A | 2021-03-26 | |||
| US20200172559A1 | 2020-06-04 | |||
| US20210228719A1 | 2021-07-29 |
Other References:
LONG KAIQI, WANG YIFAN, LV WEN, YANG YANG, XU SHUTING, ZHAN CHANGYOU, WANG WEIPING: "Photoresponsive prodrug‐dye nanoassembly for in‐situ monitorable cancer therapy", BIOENGINEERING & TRANSLATIONAL MEDICINE, vol. 7, no. 3, 1 September 2022 (2022-09-01), pages e10311, XP093057844, ISSN: 2380-6761, DOI: 10.1002/btm2.10311
LIN WENHAI, SUN TINGTING, XIE ZHIGANG, GU JINGKAI, JING XIABIN: "A dual-responsive nanocapsule via disulfide-induced self-assembly for therapeutic agent delivery", CHEMICAL SCIENCE, ROYAL SOCIETY OF CHEMISTRY, UNITED KINGDOM, vol. 7, no. 3, 1 January 2016 (2016-01-01), United Kingdom , pages 1846 - 1852, XP093057846, ISSN: 2041-6520, DOI: 10.1039/C5SC03707G
WEN LV; KAIQI LONG; YANG YANG; SIJIE CHEN; CHANGYOU ZHAN; WEIPING WANG: "A Red Light‐Triggered Drug Release System Based on One‐Photon Upconversion‐Like Photolysis", ADVANCED HEALTHCARE MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 9, no. 21, 28 September 2020 (2020-09-28), DE , XP072470109, ISSN: 2192-2640, DOI: 10.1002/adhm.202001118
LV WEN, LI YAFEI, LI FEIYANG, LAN XIN, ZHANG YAMING, DU LILI, ZHAO QIANG, PHILLIPS DAVID L., WANG WEIPING: "Upconversion-like Photolysis of BODIPY-Based Prodrugs via a One-Photon Process", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 141, no. 44, 6 November 2019 (2019-11-06), pages 17482 - 17486, XP093057851, ISSN: 0002-7863, DOI: 10.1021/jacs.9b09034
YU NINGYUE; DING MENGBIN; WANG FENGSHUO; ZHOU JIANHUI; SHI XIANGYANG; CAI RONG; LI JINGCHAO: "Near-infrared photoactivatable semiconducting polymer nanocomplexes with bispecific metabolism interventions for enhanced cancer immunotherapy", NANO TODAY, ELSEVIER, AMSTERDAM, NL, vol. 46, 29 August 2022 (2022-08-29), NL , XP087188083, ISSN: 1748-0132, DOI: 10.1016/j.nantod.2022.101600
LIN WENHAI, SUN TINGTING, XIE ZHIGANG, GU JINGKAI, JING XIABIN: "A dual-responsive nanocapsule via disulfide-induced self-assembly for therapeutic agent delivery", CHEMICAL SCIENCE, ROYAL SOCIETY OF CHEMISTRY, UNITED KINGDOM, vol. 7, no. 3, 1 January 2016 (2016-01-01), United Kingdom , pages 1846 - 1852, XP093057846, ISSN: 2041-6520, DOI: 10.1039/C5SC03707G
WEN LV; KAIQI LONG; YANG YANG; SIJIE CHEN; CHANGYOU ZHAN; WEIPING WANG: "A Red Light‐Triggered Drug Release System Based on One‐Photon Upconversion‐Like Photolysis", ADVANCED HEALTHCARE MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 9, no. 21, 28 September 2020 (2020-09-28), DE , XP072470109, ISSN: 2192-2640, DOI: 10.1002/adhm.202001118
LV WEN, LI YAFEI, LI FEIYANG, LAN XIN, ZHANG YAMING, DU LILI, ZHAO QIANG, PHILLIPS DAVID L., WANG WEIPING: "Upconversion-like Photolysis of BODIPY-Based Prodrugs via a One-Photon Process", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 141, no. 44, 6 November 2019 (2019-11-06), pages 17482 - 17486, XP093057851, ISSN: 0002-7863, DOI: 10.1021/jacs.9b09034
YU NINGYUE; DING MENGBIN; WANG FENGSHUO; ZHOU JIANHUI; SHI XIANGYANG; CAI RONG; LI JINGCHAO: "Near-infrared photoactivatable semiconducting polymer nanocomplexes with bispecific metabolism interventions for enhanced cancer immunotherapy", NANO TODAY, ELSEVIER, AMSTERDAM, NL, vol. 46, 29 August 2022 (2022-08-29), NL , XP087188083, ISSN: 1748-0132, DOI: 10.1016/j.nantod.2022.101600
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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