Title:
PHOTOCROSSLINKING OF DIETHYL FUMARATE/POLY(PROPYLENE FUMARATE) BIOMATERIALS
Document Type and Number:
WIPO Patent Application WO2003002490
Kind Code:
A3
Abstract:
A polymer network formed by crosslinking poly(propylene fumarate) with a fumarate derivative. The fumarate derivative is one in which the PPF is soluble, is preferably an alkyl fumarate, and is more preferably selected from the group consisting of diethyl fumarate, dimethyl fumarate, methyl ethyl fumarate, diisopropyl fumarate, and dibutyl fumarate. The network can be formed by photo-crosslinking and can be porous. In some embodiments, the poly(propylene fumarate) and the fumarate derivative are each present in an amount effective to produce a polymeric network useful for in vivo applications. The network can be formed from an injectable, in situ crosslinkable composite formulation, or can be prefabricated from a crosslinkable composite formulation such as stereolithography, rapid prototyping, injection molding, and extrusion molding.
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Inventors:
FISHER JOHN P
MIKOS ANTONIOS G
MIKOS ANTONIOS G
Application Number:
PCT/US2002/020425
Publication Date:
February 26, 2004
Filing Date:
June 28, 2002
Export Citation:
Assignee:
UNIV WM MARSH RICE (US)
International Classes:
C08G63/91; A61L27/18; C08L67/06; (IPC1-7): C08G63/91; C08J9/26
Foreign References:
| US4722948A | 1988-02-02 | |||
| US6124373A | 2000-09-26 | |||
| US5733951A | 1998-03-31 | |||
| US20020171178A1 | 2002-11-21 | |||
| US6283997B1 | 2001-09-04 |
Other References:
See also references of EP 1409566A4
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