Title:
PHOTOTHERMAL AGENTS
Document Type and Number:
WIPO Patent Application WO/2020/015700
Kind Code:
A1
Abstract:
A photothermal agent can be used in both photoacoustic imaging (PAI) and photothermal therapy (PTT) applications. The photothermal agent can include a small molecule, organic compound and/or polymers with absorption in the near-infrared (NIR) interrogation window (700-900 nm). The compound can be a biocompatible organic nanoparticle (ONP). The photothermal agent can be administered to a patient to locate a tumor site in the patient using in vivo imaging techniques. Once the tumor site has been determined, the tumor site can be irradiated with near-infrared light to stop or inhibit the growth of the tumor.
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Inventors:
TANG BENZHONG (CN)
ZHAO ZHENG (CN)
LIU SHUNJIE (CN)
DING DAN (CN)
ZHAO ZHENG (CN)
LIU SHUNJIE (CN)
DING DAN (CN)
Application Number:
PCT/CN2019/096536
Publication Date:
January 23, 2020
Filing Date:
July 18, 2019
Export Citation:
Assignee:
UNIV HONG KONG SCI & TECH (CN)
International Classes:
A61K31/33; C07D471/06; A61P35/00; C07D403/04; C07D409/14; C07D495/22; C07D513/04
Domestic Patent References:
| WO2014017983A1 | 2014-01-30 | |||
| WO2017190345A1 | 2017-11-09 |
Foreign References:
| CN107973792A | 2018-05-01 |
Other References:
LIU S.J. ET AL.: "Molecular Motion in Aggregates: Manipulating TICT for Boosting Photothermal Theranostics", J.AM.CHEM.SOC., vol. 141, no. 13, 13 March 2019 (2019-03-13), pages 5359 - 5368, XP055677759
QI J. ET AL.: "Highly Stable Organic Small Molecular Nanoparticles as an Advanced and Biocompatible Phototheranostic Agent of Tumor in Living Mice", ACSNANO, vol. 11, no. 7, 10 July 2017 (2017-07-10), pages 7177 - 7188, XP055677760
KEERTHI A. ET AL.: "Regioisomers of Perylenediimide:Synthesis, Photophysical, and Electrochemical Properties", J.PHYS.CHEM.B, vol. 116, no. 15, 22 March 2012 (2012-03-22), pages 4603 - 4614, XP055677763, ISSN: 1520-5207
WU W.T. ET AL.: "Synthesis of largely pi-extended naphthalenediimides via C-Hactivation towards highly soluble and narrow band-gap organic optoelectronic materials", ORG.CHEM.FRONT., vol. 4, no. 5, 22 March 2017 (2017-03-22), pages 823 - 827, ISSN: 2052-4129
BRYMORA K. ET AL.: "Computational design of quadrupolar donor-acceptor-donor molecules with near-infrared light-harvesting capabilities", DYES AND PIGMENTS, vol. 149, 5 December 2017 (2017-12-05), pages 882 - 892, XP085306316, ISSN: 0143-7208, DOI: 10.1016/j.dyepig.2017.12.003
PLUCZYK S. ET AL.: "UV-vis and EPR spectroelectrochemical investigations of triarylamine functionalized arylene bisimides", RSC ADV., vol. 5, no. 10, 19 December 2014 (2014-12-19), pages 7401 - 7412, XP055677781, ISSN: 2046-2069
QI J. ET AL.: "Highly Stable Organic Small Molecular Nanoparticles as an Advanced and Biocompatible Phototheranostic Agent of Tumor in Living Mice", ACSNANO, vol. 11, no. 7, 10 July 2017 (2017-07-10), pages 7177 - 7188, XP055677760
KEERTHI A. ET AL.: "Regioisomers of Perylenediimide:Synthesis, Photophysical, and Electrochemical Properties", J.PHYS.CHEM.B, vol. 116, no. 15, 22 March 2012 (2012-03-22), pages 4603 - 4614, XP055677763, ISSN: 1520-5207
WU W.T. ET AL.: "Synthesis of largely pi-extended naphthalenediimides via C-Hactivation towards highly soluble and narrow band-gap organic optoelectronic materials", ORG.CHEM.FRONT., vol. 4, no. 5, 22 March 2017 (2017-03-22), pages 823 - 827, ISSN: 2052-4129
BRYMORA K. ET AL.: "Computational design of quadrupolar donor-acceptor-donor molecules with near-infrared light-harvesting capabilities", DYES AND PIGMENTS, vol. 149, 5 December 2017 (2017-12-05), pages 882 - 892, XP085306316, ISSN: 0143-7208, DOI: 10.1016/j.dyepig.2017.12.003
PLUCZYK S. ET AL.: "UV-vis and EPR spectroelectrochemical investigations of triarylamine functionalized arylene bisimides", RSC ADV., vol. 5, no. 10, 19 December 2014 (2014-12-19), pages 7401 - 7412, XP055677781, ISSN: 2046-2069
Attorney, Agent or Firm:
TEE & HOWE INTELLECTUAL PROPERTY ATTORNEYS (CN)
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