Title:
PHTHALAZINE DERIVATIVES AND REMEDIES FOR ERECTILE DYSFUNCTION
Document Type and Number:
WIPO Patent Application WO/1999/042452
Kind Code:
A1
Abstract:
Phthalazine derivatives represented by general formula (I) or pharmacologically acceptable salts thereof or hydrates of the same usable as remedies for erectile dysfunction, wherein R¿1? and R¿2? are the same or different and each represents halogeno, optionally halogenated alkyl or alkoxy, or cyano; X represents cyano, nitro, halogeno, optionally substituted hydroxyimino or optionally substituted heteroaryl; and Y represents heteroaryl, aryl, alkynyl, alkenyl, alkyl or cyclic amine.
Inventors:
WATANABE NOBUHISA (JP)
KARIBE NORIO (JP)
MIYAZAKI KAZUKI (JP)
OZAKI FUMIHIRO (JP)
KAMADA ATSUSHI (JP)
MIYAZAWA SHUHEI (JP)
NAOE YOSHIMITSU (JP)
KANEKO TOSHIHIKO (JP)
TSUKADA ITARU (JP)
NAGAKURA TADASHI (JP)
ISHIHARA HIROKI (JP)
KODAMA KOHTAROU (JP)
ADACHI HIDEYUKI (JP)
KARIBE NORIO (JP)
MIYAZAKI KAZUKI (JP)
OZAKI FUMIHIRO (JP)
KAMADA ATSUSHI (JP)
MIYAZAWA SHUHEI (JP)
NAOE YOSHIMITSU (JP)
KANEKO TOSHIHIKO (JP)
TSUKADA ITARU (JP)
NAGAKURA TADASHI (JP)
ISHIHARA HIROKI (JP)
KODAMA KOHTAROU (JP)
ADACHI HIDEYUKI (JP)
Application Number:
PCT/JP1999/000688
Publication Date:
August 26, 1999
Filing Date:
February 17, 1999
Export Citation:
Assignee:
EISAI CO LTD (JP)
WATANABE NOBUHISA (JP)
KARIBE NORIO (JP)
MIYAZAKI KAZUKI (JP)
OZAKI FUMIHIRO (JP)
KAMADA ATSUSHI (JP)
MIYAZAWA SHUHEI (JP)
NAOE YOSHIMITSU (JP)
KANEKO TOSHIHIKO (JP)
TSUKADA ITARU (JP)
NAGAKURA TADASHI (JP)
ISHIHARA HIROKI (JP)
KODAMA KOHTAROU (JP)
ADACHI HIDEYUKI (JP)
WATANABE NOBUHISA (JP)
KARIBE NORIO (JP)
MIYAZAKI KAZUKI (JP)
OZAKI FUMIHIRO (JP)
KAMADA ATSUSHI (JP)
MIYAZAWA SHUHEI (JP)
NAOE YOSHIMITSU (JP)
KANEKO TOSHIHIKO (JP)
TSUKADA ITARU (JP)
NAGAKURA TADASHI (JP)
ISHIHARA HIROKI (JP)
KODAMA KOHTAROU (JP)
ADACHI HIDEYUKI (JP)
International Classes:
A61K31/50; A61K31/501; A61P15/00; A61P15/10; C07D237/28; C07D237/34; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/04; C07D403/06; C07D409/14; C07D411/14; C07D417/04; C07D417/14; C07D451/06; C07D471/08; C07D491/04; C07D491/08; C07D491/10; C07D491/107; C07D491/113; C07D498/08; C07D521/00; (IPC1-7): C07D237/34; A61K31/50; C07D401/04; C07D401/06; C07D403/04; C07D403/06; C07D491/107; C07D498/08
Domestic Patent References:
| WO1998007430A1 | 1998-02-26 | |||
| WO1986005176A1 | 1986-09-12 | |||
| WO1996005176A1 | 1996-02-22 |
Foreign References:
| JPH06135938A | 1994-05-17 | |||
| JPH08225541A | 1996-09-03 | |||
| EP0920868A1 | 1999-06-09 | |||
| EP0722936A1 | 1996-07-24 |
Other References:
INT. J. IMPOTENCE RES., vol. A, 1992, pages 85 - 93
J. UROL., vol. 147, 1992, pages 1650 - 1655
N. ENGL. J. MED., vol. 326, 1992, pages 90 - 94
See also references of EP 1057819A4
J. UROL., vol. 147, 1992, pages 1650 - 1655
N. ENGL. J. MED., vol. 326, 1992, pages 90 - 94
See also references of EP 1057819A4
Attorney, Agent or Firm:
Furuya, Kaoru (Nihonbashi-Horidomecho Chuo-ku Tokyo, JP)
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