Title:
PHTHALAZINONE COMPOUNDS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/242245
Kind Code:
A1
Abstract:
The present invention relates to: a phthalazinone compound, or a racemate, stereoisomer, or pharmaceutically acceptable salt thereof; a pharmaceutical composition for the prevention or treatment of Sirt6-associated diseases, comprising, as an active ingredient, a phthalazinone compound, or a racemate, stereoisomer, or pharmaceutically acceptable salt thereof; and a method for treating Sirt6-associated diseases comprising administering a phthalazinone compound, or a racemate, stereoisomer, or pharmaceutically acceptable salt thereof to a subject in need of this.
Inventors:
KIM KYUNGJIN (KR)
KIM KWANGROK (KR)
KIM UK-IL (KR)
BANG HYUNG TAE (KR)
LEE SEUL KI (KR)
JEONG KWAN-YOUNG (KR)
KANG SEUNG KYU (KR)
JUNG HEEJUNG (KR)
LEE SANG DAL (KR)
JUNG WON HOON (KR)
LEE JUN MI (KR)
KIM KWANGROK (KR)
KIM UK-IL (KR)
BANG HYUNG TAE (KR)
LEE SEUL KI (KR)
JEONG KWAN-YOUNG (KR)
KANG SEUNG KYU (KR)
JUNG HEEJUNG (KR)
LEE SANG DAL (KR)
JUNG WON HOON (KR)
LEE JUN MI (KR)
Application Number:
PCT/KR2020/006995
Publication Date:
December 03, 2020
Filing Date:
May 29, 2020
Export Citation:
Assignee:
ST PHARM CO LTD (KR)
KOREA RES INST CHEMICAL TECH (KR)
KOREA RES INST CHEMICAL TECH (KR)
International Classes:
C07D237/32; A61K31/502; A61P1/16; A61P35/00
Domestic Patent References:
| WO2016139361A1 | 2016-09-09 |
Foreign References:
| US5624922A | 1997-04-29 |
Other References:
DATABASE Registry CAS; 3 January 2003 (2003-01-03), "- 1(2H)-Phthalazinone, 2-(4-bromophenyl)-7-fluoro-4-(4-fluorophenyl)-", XP055764759, retrieved from STN Database accession no. RN 478066-05-6
DATABASE Registry CAS; 30 May 2001 (2001-05-30), "- 1(2H)-Phthalazinone, 7-fluoro-4-(4-fluorophenyl)-2-[4- (trifluoromethyl)phenyl]-", XP055764768, retrieved from STN Database accession no. RN 339009-72-2
DATABASE Registry CAS; 30 May 2001 (2001-05-30), "- 1(2H)-Phthalazinone, 7-fluoro-2,4-bis(4-fluorophenyl)-", XP055764773, retrieved from STN Database accession no. RN 339009-71-1
DATABASE Registry CAS; 4 March 2018 (2018-03-04), "1(2H)-Phthalazinone, 8-chloro-2,4-diphenyl-", XP055764779, retrieved from STN Database accession no. RN2184101-07-1
DATABASE Registry CAS; 4 March 2018 (2018-03-04), "- 1(2H)-Phthalazinone, 7-chloro-2,4-diphenyl-", XP055764784, retrieved from STN Database accession no. RN2183741-74-2
DATABASE Registry CAS; 1 March 2018 (2018-03-01), "- 1(2H)-Phthalazinone, 7-chloro-4-phenyl-2-propyl-", XP055764787, retrieved from STN Database accession no. RN 2182402-34-0
HAMEED, A. DH. ET AL.: "Synthesis and Biological Evaluation of New Phthalazinone Derivatives as Anti-Inflammatory and Anti-Proliferative Agents", ARCH. PHARM. CHEM. LIFE SCI., vol. 349, 2016, pages 150 - 159, XP055861161
PROC. NATL. ACAD. SCI. U S A., vol. 107, 2010, pages 21790 - 21794
CELL METAB, vol. 12, 2010, pages 224 - 236
CELL, vol. 151, 2012, pages 1185 - 1199
J. BIOL. CHEM., vol. 287, 2012, pages 41903 - 41913
NATURE, vol. 460, 2009, pages 587 - 591
SCI. REP., vol. 3, 2013, pages 3085
CURR. TOP. MED. CHEM., vol. 13, 2013, pages 2991 - 3000
NATURE, vol. 452, 2008, pages 492 - 496
CELL, vol. 136, 2009, pages 62 - 74
CYCLE, vol. 8, 2009, pages 2664 - 2666
NAT. STRUCT. MOL. BIOL., vol. 23, 2016, pages 434 - 440
CELL, vol. 140, 2010, pages 280 - 293
See also references of EP 3978480A4
DATABASE Registry CAS; 30 May 2001 (2001-05-30), "- 1(2H)-Phthalazinone, 7-fluoro-4-(4-fluorophenyl)-2-[4- (trifluoromethyl)phenyl]-", XP055764768, retrieved from STN Database accession no. RN 339009-72-2
DATABASE Registry CAS; 30 May 2001 (2001-05-30), "- 1(2H)-Phthalazinone, 7-fluoro-2,4-bis(4-fluorophenyl)-", XP055764773, retrieved from STN Database accession no. RN 339009-71-1
DATABASE Registry CAS; 4 March 2018 (2018-03-04), "1(2H)-Phthalazinone, 8-chloro-2,4-diphenyl-", XP055764779, retrieved from STN Database accession no. RN2184101-07-1
DATABASE Registry CAS; 4 March 2018 (2018-03-04), "- 1(2H)-Phthalazinone, 7-chloro-2,4-diphenyl-", XP055764784, retrieved from STN Database accession no. RN2183741-74-2
DATABASE Registry CAS; 1 March 2018 (2018-03-01), "- 1(2H)-Phthalazinone, 7-chloro-4-phenyl-2-propyl-", XP055764787, retrieved from STN Database accession no. RN 2182402-34-0
HAMEED, A. DH. ET AL.: "Synthesis and Biological Evaluation of New Phthalazinone Derivatives as Anti-Inflammatory and Anti-Proliferative Agents", ARCH. PHARM. CHEM. LIFE SCI., vol. 349, 2016, pages 150 - 159, XP055861161
PROC. NATL. ACAD. SCI. U S A., vol. 107, 2010, pages 21790 - 21794
CELL METAB, vol. 12, 2010, pages 224 - 236
CELL, vol. 151, 2012, pages 1185 - 1199
J. BIOL. CHEM., vol. 287, 2012, pages 41903 - 41913
NATURE, vol. 460, 2009, pages 587 - 591
SCI. REP., vol. 3, 2013, pages 3085
CURR. TOP. MED. CHEM., vol. 13, 2013, pages 2991 - 3000
NATURE, vol. 452, 2008, pages 492 - 496
CELL, vol. 136, 2009, pages 62 - 74
CYCLE, vol. 8, 2009, pages 2664 - 2666
NAT. STRUCT. MOL. BIOL., vol. 23, 2016, pages 434 - 440
CELL, vol. 140, 2010, pages 280 - 293
See also references of EP 3978480A4
Attorney, Agent or Firm:
LEE, Seongsu (KR)
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