Title:
PHYSIOLOGICALLY-RELEVANT, SERUM-FREE IN VITRO ANGIOGENESIS PLATFORM
Document Type and Number:
WIPO Patent Application WO/2023/133523
Kind Code:
A3
Abstract:
A custom platform is developed that is capable of culturing endothelial cells three-dimensionally while inducing physiological stimuli on the cells. A model includes serum-free conditions, allowing more quantifiable angiogenesis studies that investigate the dose dependent effects of various growth factors. Angiogenesis plays a critical role during development, wound healing, and disease; therefore, further investigation of the pathway has broad implications. Also, the development of in vitro vascularized tissue models via angiogenesis provides the ability to investigate endothelial responses after exposure to nanoparticles and mechanisms of drug delivery.
Inventors:
BRUNMAIER LAURA A E (US)
WALKER TRAVIS W (US)
MILLER CYLE (US)
BRENZA TIMOTHY M (US)
WALKER TRAVIS W (US)
MILLER CYLE (US)
BRENZA TIMOTHY M (US)
Application Number:
PCT/US2023/060256
Publication Date:
August 31, 2023
Filing Date:
January 06, 2023
Export Citation:
Assignee:
SOUTH DAKOTA BOARD OF REGENTS (US)
International Classes:
B01L3/00; C12M1/32; C12M1/12
Foreign References:
| US20170009194A1 | 2017-01-12 | |||
| US20180296343A1 | 2018-10-18 | |||
| US20210354104A1 | 2021-11-18 | |||
| US6491422B1 | 2002-12-10 |
Attorney, Agent or Firm:
COLEMAN, Kyle S. et al. (US)
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