Title:
PIGMENT EPITHELIUM-DERIVED FACTOR, NOVEL BIOLOGICAL ACTIVITY AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO2005041887
Kind Code:
A3
Abstract:
The present invention relates to method of treating a patient with a condition involving increased vascular permeability or increased angiogenesis comprising administering to the patient a therapeutically effective amount of PEDF, PEDF 44 AA peptide, a homolog of the PEDF 44 AA peptide, a homolog of the PEDF 44 AA peptide wherein amino acid residues glutamateat the (101) amino acid position, isoleucine at the (103) amino acid position, leucine at the (112) and serine at the (115) amino acid position are unchanged, or an agent that activates the PEDF receptor. Conditions for treatment include, but are not limited to, sepsis acute respiratory distress syndrome, nephrotic syndrome, diabetic neuropathy, preproliferative diabetic retinopathy, cancer or proliferative diabetic retinopathy.
Inventors:
TONG PATRICK (US)
LIU HUA (US)
LIU HUA (US)
Application Number:
PCT/US2004/036245
Publication Date:
November 24, 2005
Filing Date:
October 29, 2004
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
TONG PATRICK (US)
LIU HUA (US)
TONG PATRICK (US)
LIU HUA (US)
International Classes:
A61K38/18; A61K; (IPC1-7): A61K38/18
Foreign References:
| US6451763B1 | 2002-09-17 | |||
| US20010021382A1 | 2001-09-13 |
Other References:
LECHIN A.E. AND VARON J. ET AL: "Adult Respiratory Distress Syndrome (ARDS): The basics.", JOURNAL OF EMERGENCY MEDICINE., vol. 12, 1994, pages 63 - 68, XP002990551
ABRAMSON L.P. ET AL: "Wilms' tumor growth is suppressed by antiangiogenic pigment epithelium-derived factor in a xenograft model.", JOURNAL OF PEDIATRIC SURGERY., vol. 38, no. 3, 2003, pages 336 - 342, XP002990552
DUH E.J. ET AL: "Pigment epithelium -derived factor suppresses ischemia-induces retinal neovascularization and VEGF-induced migration and growth.", INVESTIGATIVE OPTHALMOLOGY AND VISUAL SCIENCE., vol. 43, 2002, pages 821 - 829, XP002990553
STELLMATCH V. ET AL: "Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor.", PNAS., vol. 98, no. 5, 2001, pages 2593 - 2597, XP002990554
OSTERBY R. ET AL: "Neovascularization at the vascular pole region in diabetic glomerulophaty.", NEPHROLOGY DIALYSIS TRANSPLANTATION., vol. 14, no. 2, 1999, pages 348 - 352, XP002990555
BLOM M.L. ET AL: "Diabetic retinopathy.", DEL.MED.JRL., vol. 66, 1994, pages 379 - 388, XP008052296
ABRAMSON L.P. ET AL: "Wilms' tumor growth is suppressed by antiangiogenic pigment epithelium-derived factor in a xenograft model.", JOURNAL OF PEDIATRIC SURGERY., vol. 38, no. 3, 2003, pages 336 - 342, XP002990552
DUH E.J. ET AL: "Pigment epithelium -derived factor suppresses ischemia-induces retinal neovascularization and VEGF-induced migration and growth.", INVESTIGATIVE OPTHALMOLOGY AND VISUAL SCIENCE., vol. 43, 2002, pages 821 - 829, XP002990553
STELLMATCH V. ET AL: "Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor.", PNAS., vol. 98, no. 5, 2001, pages 2593 - 2597, XP002990554
OSTERBY R. ET AL: "Neovascularization at the vascular pole region in diabetic glomerulophaty.", NEPHROLOGY DIALYSIS TRANSPLANTATION., vol. 14, no. 2, 1999, pages 348 - 352, XP002990555
BLOM M.L. ET AL: "Diabetic retinopathy.", DEL.MED.JRL., vol. 66, 1994, pages 379 - 388, XP008052296
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