Title:
PIPER NIGRUM L. ESSENTIAL OIL WITH ANTI-INFLAMMATORY ACTIVITY AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/155315
Kind Code:
A1
Abstract:
Provided is a preparation method of a Piper nigrum L. essential oil with anti-inflammatory activity, which comprises: performing ultralow-temperature freezing, microwave thawing, pulp grinding, enzymolysis, steam distillation, and oil-water separation on fresh Piper nigrum L. fruits to obtain a Piper nigrum L. essential oil. Experiments have shown that the Piper nigrum L. essential oil has an inhibitory effect on the release of nitric oxide (NO) by RAW 264.7 cells, the release of tumor necrosis factor (TNF‑ɑ), interleukin-6 (IL-6), interleukin-1β (IL‑1β) and prostaglandin E2 (PGE2), and the expression of cyclooxygenase-2 (COX-2), which indicates that the Piper nigrum L. essential oil has anti-inflammatory activity.
Inventors:
GU FENGLIN (CN)
WU GUIPING (CN)
DUAN MENGYA (CN)
LI XIN (CN)
ZHU HONGYING (CN)
ZONG YING (CN)
WU GUIPING (CN)
DUAN MENGYA (CN)
LI XIN (CN)
ZHU HONGYING (CN)
ZONG YING (CN)
Application Number:
PCT/CN2022/093758
Publication Date:
August 24, 2023
Filing Date:
May 19, 2022
Export Citation:
Assignee:
SPICE AND BEVERAGE RES INSTITUTE CHINESE ACADEMY OF TROPICAL AGRICULTURAL SCIENCES CATAS (CN)
International Classes:
C11B9/02; A61K36/67; A61P29/00
Foreign References:
| CN103349006A | 2013-10-16 | |||
| CN107223943A | 2017-10-03 | |||
| CN109554227A | 2019-04-02 | |||
| CN106900884A | 2017-06-30 | |||
| CN103039931A | 2013-04-17 | |||
| CN102260594A | 2011-11-30 | |||
| CN107281032A | 2017-10-24 | |||
| CN110591819A | 2019-12-20 | |||
| CN103484256A | 2014-01-01 | |||
| CN112063305A | 2020-12-11 | |||
| US20130280320A1 | 2013-10-24 |
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (CN)
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