Title:
PIPERAZINE AMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2020/207419
Kind Code:
A1
Abstract:
The present invention relates to a piperazine amide derivative as represented by formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition thereof, and use of same as a therapeutic agent, especially as a selective Rearranged During Transfection (RET) kinase inhibitor. Ring a, ring e, X1, X2, X3, X4, R1, R2, R3, R4, R4', R5, R5', R6, R6', R7, R7', R8, m, and n have the same definitions as those in the specification.
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Inventors:
ZHANG PANPAN (CN)
YAN SUNLI (CN)
LI YING (CN)
GUO CHENLI (CN)
QIAN WENJIAN (CN)
YE CHENG (CN)
SHI ZHENGZHENG (CN)
HU TAISHAN (CN)
CHEN LEI (CN)
YAN SUNLI (CN)
LI YING (CN)
GUO CHENLI (CN)
QIAN WENJIAN (CN)
YE CHENG (CN)
SHI ZHENGZHENG (CN)
HU TAISHAN (CN)
CHEN LEI (CN)
Application Number:
PCT/CN2020/083854
Publication Date:
October 15, 2020
Filing Date:
April 09, 2020
Export Citation:
Assignee:
ZHEJIANG HISUN PHARM CO LTD (CN)
International Classes:
C07D401/14; A61K31/506; A61P35/00; C07D403/04
Domestic Patent References:
| WO2016127074A1 | 2016-08-11 | |||
| WO2018017983A1 | 2018-01-25 | |||
| WO2017161269A1 | 2017-09-21 | |||
| WO2016127074A1 | 2016-08-11 | |||
| WO2017079140A1 | 2017-05-11 | |||
| WO2017011776A1 | 2017-01-19 | |||
| WO2017161269A1 | 2017-09-21 | |||
| WO2018017983A1 | 2018-01-25 | |||
| WO2018022761A1 | 2018-02-01 | |||
| WO2018071454A1 | 2018-04-19 | |||
| WO2018136661A1 | 2018-07-26 | |||
| WO2018136663A1 | 2018-07-26 |
Foreign References:
| CN108473468A | 2018-08-31 | |||
| CN201910294193A | 2019-04-12 |
Other References:
"McGraw-Hill Dictionary of Chemical Terms", 1984, MCGRAW-HILLBOOK COMPANY
ELIEL, E.WILEN, S.: "Stereochemistry of Organic Compounds", 1994, JOHN WILEY & SONS, INC.
ELIEL, E.WILEN, S.: "Stereochemistry of Organic Compounds", 1994, JOHN WILEY & SONS, INC.
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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