PIPERAZINE DERIVATIVES AS HIV PROTEASE INHIBITORS

Title:

PIPERAZINE DERIVATIVES AS HIV PROTEASE INHIBITORS

Document Type and Number:

WIPO Patent Application WO/2015/017393

Kind Code:

A3

Abstract:

The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.

Inventors:

WILLIAMS PETER D (US)
MCCAULEY JOHN A (US)
BENNETT DAVID J (US)
BUNGARD CHRISTOPHER J (US)
CHANG LEHUA (US)
CHU XIN-JIE (CN)
DWYER MICHAEL P (US)
HOLLOWAY M KATHERINE (US)
KEERTIKAR KARTIK M (US)
LOUGHRAN H MARIE (US)
MANIKOWSKI JESSE J (US)
MORRIELLO GREGORI J (US)
SHEN DONG-MING (US)
SHERER EDWARD C (US)
SCHULZ JURGEN (GB)
WADDELL SHERMAN TIM (US)
WISCOUNT CATHERINE M (US)
ZORN NICOLAS (FR)
SATYANARAYANA TUMMANAPALLI (US)
VIJAYASARADHI SIVALENKA (US)
HU BIN (CN)
JI TAO (CN)
ZHONG BIN (CN)

Application Number:

PCT/US2014/048581

Publication Date:

November 05, 2015

Filing Date:

July 29, 2014

Export Citation:

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Assignee:

MERCK SHARP & DOHME (US)
MSD R & D CHINA CO LTD (CN)
WILLIAMS PETER D (US)
MCCAULEY JOHN A (US)
BENNETT DAVID J (US)
BUNGARD CHRISTOPHER J (US)
CHANG LEHUA (US)
CHU XIN-JIE (CN)
DWYER MICHAEL P (US)
HOLLOWAY M KATHERINE (US)
KEERTIKAR KARTIK M (US)
LOUGHRAN H MARIE (US)
MANIKOWSKI JESSE J (US)
MORRIELLO GREGORI J (US)
SHEN DONG-MING (US)
SHERER EDWARD C (US)
SCHULZ JUERGEN (GB)
WADDELL SHERMAN TIM (US)
WISCOUNT CATHERINE M (US)
ZORN NICOLAS (FR)
SATYANARAYANA TUMMANAPALLI (US)
VIJAYASARADHI SIVALENKA (US)
HU BIN (CN)
JI TAO (CN)
ZHONG BIN (CN)

International Classes:

C07D295/088

Foreign References:

US20100121048A1	2010-05-13
US7727991B2	2010-06-01
US6531476B1	2003-03-11
US5981520A	1999-11-09

Other References: