Title:
PIPERAZINONE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/232113
Kind Code:
A1
Abstract:
Disclosed are a piperazinone compound, a preparation method therefor and a use thereof. Specifically, disclosed are a compound represented by formula I, and a tautomer, stereoisomer or pharmaceutically acceptable salt thereof. The compound represented by formula I has a good inhibitory effect on tumor cell proliferation, and relatively good pharmacokinetic properties.
Inventors:
YANG KANGMIN (CN)
WU JING (CN)
WU JING (CN)
Application Number:
PCT/CN2023/097817
Publication Date:
December 07, 2023
Filing Date:
June 01, 2023
Export Citation:
Assignee:
SHANGHAI XUCHENG PHARMATECH CO LTD (CN)
International Classes:
C07D403/06; A61K31/496; A61K31/4985; A61P35/00; C07D487/14
Domestic Patent References:
| WO2012035436A1 | 2012-03-22 | |||
| WO2007035841A1 | 2007-03-29 |
Foreign References:
| JP2020189806A | 2020-11-26 | |||
| JP2015030679A | 2015-02-16 | |||
| CN1684955A | 2005-10-19 |
Other References:
DING, ZHONGPENG ET AL.: "Development of Novel Phenoxy-Diketopiperazine-Type Plinabulin Derivatives as Potent Antimicrotubule Agents Based on the Co-crystal Structure", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 28, 11 November 2019 (2019-11-11), XP085966893, DOI: 10.1016/j.bmc.2019.115186
DATABASE Registry CAS; 12 May 2020 (2020-05-12), ANONYMOUS : "2,5-Piperazinedione, 1-acetyl-3- [[3-(4-fluorophenoxy)pheny l]methylene]-, (3Z)- ", XP093116319, retrieved from STN Database accession no. 2416338-70-8
DATABASE Registry CAS; 17 March 2020 (2020-03-17), ANONYMOUS : "2,5-Piperazinedione, 1-acetyl-3- [[1-butyl-5-(1,1-dimethyleth yl)-1Himidazol-4-yl]methylene]-, (3Z)-", XP093116322, retrieved from STN Database accession no. 2411962-96-2
DATABASE Registry CAS; 12 May 2020 (2020-05-12), ANONYMOUS : "2,5-Piperazinedione, 3-[[3-(4-fluor ophenoxy)phenyl]methylene] -6-[(4-methyl1H-imidazol-5-yl)methylene]-, (3Z,6Z)", XP093116316, retrieved from STN Database accession no. 2416338-46-8
DATABASE Registry CAS; 12 May 2020 (2020-05-12), ANONYMOUS : "2,5-Piperazinedione, 1-acetyl-3- [[3-(4-fluorophenoxy)pheny l]methylene]-, (3Z)- ", XP093116319, retrieved from STN Database accession no. 2416338-70-8
DATABASE Registry CAS; 17 March 2020 (2020-03-17), ANONYMOUS : "2,5-Piperazinedione, 1-acetyl-3- [[1-butyl-5-(1,1-dimethyleth yl)-1Himidazol-4-yl]methylene]-, (3Z)-", XP093116322, retrieved from STN Database accession no. 2411962-96-2
DATABASE Registry CAS; 12 May 2020 (2020-05-12), ANONYMOUS : "2,5-Piperazinedione, 3-[[3-(4-fluor ophenoxy)phenyl]methylene] -6-[(4-methyl1H-imidazol-5-yl)methylene]-, (3Z,6Z)", XP093116316, retrieved from STN Database accession no. 2416338-46-8
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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