Title:
PIPERIDIN-2-ONE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THESE COMPOUNDS AS THE ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2003/043988
Kind Code:
A1
Abstract:
Piperidin-2-one derivative compounds represented by the following general formula (I) and salts thereof: wherein each symbol is as defined in the description. Because of inhibiting the activation of p38MAP kinase, the compounds represented by the general formula (I) are useful in preventing and/or treating various inflammatory diseases, rheumatoid arthritis, arthritis deformans, arthritis, osteoporosis, autoimmune diseases, infections, sepsis, cachexia, brain infarction, Alzheimer’s disease, asthma, chronic obstructive pulmonary disease, reperfusion injury, thrombosis, glomerular nephritis, diabetes, host-versus-graft rejection, inflammatory colon diseases, Crohn’s disease, ulcerative colitis, multiple sclerosis, tumor proliferation and metastasis, multiple myeloma, plasmacytoid leukemia, Castleman’s disease, intra-arterial myxoma, psoriasis, dermatitis, gout, adult respiratory distress syndrome (ARDS), arteriosclerosis, post-PTCA (percutaneous transluminal coronary angioplasty) restenosis and pancreatitis.
Inventors:
TAKAHASHI KANJI (JP)
YAMAMOTO SHINGO (JP)
NAKA MASAO (JP)
YAMAMOTO SHINGO (JP)
NAKA MASAO (JP)
Application Number:
PCT/JP2002/012174
Publication Date:
May 30, 2003
Filing Date:
November 21, 2002
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
TAKAHASHI KANJI (JP)
YAMAMOTO SHINGO (JP)
NAKA MASAO (JP)
TAKAHASHI KANJI (JP)
YAMAMOTO SHINGO (JP)
NAKA MASAO (JP)
International Classes:
A61K31/4433; A61K31/451; A61K31/4535; A61K31/454; A61K31/4545; A61K31/495; A61K31/496; A61K31/513; A61K31/535; A61K31/5375; A61K31/5377; A61P1/04; A61P1/18; A61P3/10; A61P7/00; A61P7/02; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P19/06; A61P19/10; A61P25/00; A61P25/28; A61P29/00; A61P31/00; A61P31/04; A61P35/00; C07D211/76; C07D211/86; C07D211/96; C07D239/10; C07D241/08; C07D265/10; C07D265/32; C07D401/10; C07D401/12; C07D405/12; C07D409/06; C07D413/08; C07D417/04; (IPC1-7): C07D211/76; C07D401/12; C07D211/86; C07D211/88; C07D211/96; C07D417/04; C07D409/06; C07D401/10; C07D413/10; C07D405/12; C07D239/10; C07D241/08; C07D265/10; C07D265/32; A61K31/451; A61K31/454; A61K31/4545; A61K31/496; A61K31/5377; A61K31/4535; A61K31/4433; A61K31/513; A61K31/495; A61K31/535; A61K31/5375; A61P1/04; A61P1/18; A61P3/10; A61P7/00; A61P7/02; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P19/06; A61P19/10; A61P25/00; A61P25/28; A61P29/00; A61P31/00; A61P31/04; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P43/00
Domestic Patent References:
| WO2001054694A1 | 2001-08-02 | |||
| WO2001076693A1 | 2001-10-18 | |||
| WO2000012074A2 | 2000-03-09 | |||
| WO2000071535A1 | 2000-11-30 | |||
| WO1998028292A1 | 1998-07-02 | |||
| WO1998006715A1 | 1998-02-19 | |||
| WO2002102380A1 | 2002-12-27 |
Foreign References:
| JPH04307539A | 1992-10-29 |
Other References:
FANCHER OTIS E. ET AL.: "4-Alkyl-(or aralkyl) 1-aryl-2-piperazinones", J. MED. CHEM., vol. 7, no. 2, 1964, pages 154 - 158, XP002964705
Attorney, Agent or Firm:
Ohie, Kunihisa (Horiguchi No.2 Bldg. 7F 2-6,
Nihonbashi-Ningyocho, 2-chom, Chuo-ku Tokyo, JP)
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