Title:
PIPERIDINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2006/025471
Kind Code:
A1
Abstract:
A piperidine derivative in which the piperidine ring is bonded in the 4-position to a monosubstituted or unsubstituted (-R1) benzene ring through vinylene and has an acyl group (-C(=O)-R4) in the 1-position; or a pharmaceutically acceptable salt of the derivative. The derivative and salt are excellent in sodium channel inhibitory activity and analgetic activity and have a high analgetic effect especially on neurogenic pains. The compounds are useful as a sodium channel inhibitor reduced in side effects.
Inventors:
KIKUCHI KAZUMI (JP)
FUJIYASU JIRO (JP)
WATANABE TOSHIHIRO (JP)
NAGAKURA YUKINORI (JP)
TOMIYAMA HIROSHI (JP)
SONEGAWA MOTOHARU (JP)
TOKUZAKI KAZUO (JP)
IWAI YOSHINORI (JP)
FUJIYASU JIRO (JP)
WATANABE TOSHIHIRO (JP)
NAGAKURA YUKINORI (JP)
TOMIYAMA HIROSHI (JP)
SONEGAWA MOTOHARU (JP)
TOKUZAKI KAZUO (JP)
IWAI YOSHINORI (JP)
Application Number:
PCT/JP2005/015949
Publication Date:
March 09, 2006
Filing Date:
August 31, 2005
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
KOTOBUKI PHARMACEUTICAL CO LTD (JP)
KIKUCHI KAZUMI (JP)
FUJIYASU JIRO (JP)
WATANABE TOSHIHIRO (JP)
NAGAKURA YUKINORI (JP)
TOMIYAMA HIROSHI (JP)
SONEGAWA MOTOHARU (JP)
TOKUZAKI KAZUO (JP)
IWAI YOSHINORI (JP)
KOTOBUKI PHARMACEUTICAL CO LTD (JP)
KIKUCHI KAZUMI (JP)
FUJIYASU JIRO (JP)
WATANABE TOSHIHIRO (JP)
NAGAKURA YUKINORI (JP)
TOMIYAMA HIROSHI (JP)
SONEGAWA MOTOHARU (JP)
TOKUZAKI KAZUO (JP)
IWAI YOSHINORI (JP)
International Classes:
C07D211/16; A61K31/438; A61K31/439; A61K31/445; A61K31/453; A61K31/454; A61K31/4545; A61K31/496; A61K31/5377; A61K31/55; A61K31/553; A61P25/00; A61P25/04; A61P43/00; C07D211/18; C07D211/22; C07D211/28; C07D211/34; C07D211/42; C07D211/62; C07D401/06; C07D401/12; C07D405/12; C07D413/06; C07D471/18; C07D487/08; C07D491/113
Domestic Patent References:
| WO2004011430A1 | 2004-02-05 | |||
| WO2001053288A1 | 2001-07-26 | |||
| WO2004078715A1 | 2004-09-16 |
Foreign References:
| JP2002523448A | 2002-07-30 | |||
| JPH02179A | 1990-01-05 |
Other References:
LAMONTAGNE MP ET AL: "Antimalarials. 8. Synthesis of amino ethers as candidate antimalarials.", J MED CHEM., vol. 19, no. 3, 1976, pages 360 - 365, XP002993309
Attorney, Agent or Firm:
Watanabe, Kazuhira (No.8 Kikuboshi Tower Building 20-18,
Asakusabashi 3-chom, Taito-ku Tokyo 53, JP)
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