Title:
PIPERIDINE DERIVATIVE, PIPERAZINE DERIVATIVE AND AGENT FOR TREATMENT OF DISEASE INVOLVING CENTRAL NERVOUS SYSTEM DISORDERS
Document Type and Number:
WIPO Patent Application WO/2010/050436
Kind Code:
A1
Abstract:
A novel piperidine derivative and a novel piperazine derivative which are useful as novel sigma receptor ligands, and an agent for treatment of diseases involving central nervous system disorders, said agent containing one of the compounds as an active ingredient. The agent contains a compound represented by general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient. (In the formula, X represents an alkylene group having 1-5 carbon atoms, and the alkylene group may be substituted by one or more alkyl groups each having 1-2 carbon atoms; Y represents a carbon atom or a nitrogen atom; and R1 and R2 each independently represents a hydrogen atom, a halogen atom, an alkyl group having 1-2 carbon atoms or an alkoxyl group having 1-2 carbon atoms.)
Inventors:
MITA SHIRO (JP)
KOBAYASHI NAOYUKI (JP)
KOBAYASHI NAOYUKI (JP)
Application Number:
PCT/JP2009/068341
Publication Date:
May 06, 2010
Filing Date:
October 26, 2009
Export Citation:
Assignee:
MS SCIENCE CORP (JP)
MITA SHIRO (JP)
KOBAYASHI NAOYUKI (JP)
MITA SHIRO (JP)
KOBAYASHI NAOYUKI (JP)
International Classes:
C07D211/14; A61K31/451; A61K31/495; A61P9/10; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P43/00; C07D295/02
Domestic Patent References:
| WO2007021545A2 | 2007-02-22 | |||
| WO2007021545A2 | 2007-02-22 | |||
| WO2007089462A2 | 2007-08-09 |
Foreign References:
| AT229873B | 1963-10-25 | |||
| US2858313A | 1958-10-28 | |||
| JPH11501014A | 1999-01-26 |
Other References:
NATSUKA, KAGAYAKI ET AL.: "1-Substituted 4-(1, 2-diphenylethyl)-piperazine derivatives and their analgesic activities. 1", JOURNAL OF MEDICINAL CHEMISTRY, vol. 18, no. 12, 1975, pages 1240 - 1244, XP002323139
CHEMICAL ABSTRACTS, vol. 94, 1981, Columbus, Ohio, US; abstract no. 30706, page 570; XP008148469
CHEMICAL ABSTRACTS, vol. 83, 1975, Columbus, Ohio, US; abstract no. 58749, page 498; XP008148473
LANYI, KALMAN ET AL.: "Piperazine derivatives. II. Effect of piperazine derivatives", ARZNEIMITTEL-FORSCHUNG, vol. 18, no. 11, 1968, pages 1431 - 1435, XP008148483
LANYI, KALMAN ET AL.: "Piperazine derivatives. I. Alkyl-, aryl, aralkyl-piperazine derivatives", CHEMISCHE BERICHTE, vol. 100, no. 9, 1967, pages 3045 - 3051, XP008148471
CHEMICAL ABSTRACTS, vol. 94, 1981, Columbus, Ohio, US; abstract no. 30706, page 570; XP008148469
CHEMICAL ABSTRACTS, vol. 83, 1975, Columbus, Ohio, US; abstract no. 58749, page 498; XP008148473
LANYI, KALMAN ET AL.: "Piperazine derivatives. II. Effect of piperazine derivatives", ARZNEIMITTEL-FORSCHUNG, vol. 18, no. 11, 1968, pages 1431 - 1435, XP008148483
LANYI, KALMAN ET AL.: "Piperazine derivatives. I. Alkyl-, aryl, aralkyl-piperazine derivatives", CHEMISCHE BERICHTE, vol. 100, no. 9, 1967, pages 3045 - 3051, XP008148471
Attorney, Agent or Firm:
FURUTANI, Shinya (JP)
Shin-ya Furuya (JP)
Shin-ya Furuya (JP)
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