Title:
PIPERIDINE-SUBSTITUTED BENZOIC ACID COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/099458
Kind Code:
A1
Abstract:
Disclosed in the present invention are a piperidine-substituted benzoic acid compound, and a pharmaceutical composition and the use thereof. The piperidine-substituted benzoic acid compound of the present invention is a compound as shown in formula (I) or a stereoisomer, a tautomer or an isotopic label thereof, or a pharmaceutically acceptable salt of any one of the foregoing. The compound has a good inhibitory activity on complement factor B, a good affinity activity on complement factor B, and a hemolytic activity and an inhibitory activity of an alternative complement pathway.
Inventors:
WU XUESONG (CN)
TANG ZHIWEI (CN)
WANG HONGBO (CN)
CHEN LIKUO (CN)
CHEN CHEN (CN)
MAO YANJIA (CN)
TANG ZHIWEI (CN)
WANG HONGBO (CN)
CHEN LIKUO (CN)
CHEN CHEN (CN)
MAO YANJIA (CN)
Application Number:
PCT/CN2023/131348
Publication Date:
May 16, 2024
Filing Date:
November 13, 2023
Export Citation:
Assignee:
SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY COMPANY LTD (CN)
CHINA STATE INST OF PHARMACEUTICAL INDUSTRY CO LTD (CN)
CHINA STATE INST OF PHARMACEUTICAL INDUSTRY CO LTD (CN)
International Classes:
C07D401/06; A61K31/454; A61K31/4545; A61P27/00; A61P37/00; C07D403/06
Domestic Patent References:
| WO2023187715A1 | 2023-10-05 | |||
| WO2022028507A1 | 2022-02-10 |
Foreign References:
| CN102718692A | 2012-10-10 | |||
| CN105579444A | 2016-05-11 | |||
| CN109414441A | 2019-03-01 | |||
| CN111032042A | 2020-04-17 | |||
| CN114057692A | 2022-02-18 |
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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