Title:
PIPERIDINOPYRIMIDINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2024/088296
Kind Code:
A1
Abstract:
The present disclosure relates to a piperidinopyrimidine derivative, a preparation method therefor and the use thereof in medicine. Specifically, the present disclosure relates to a piperidinopyrimidine derivative as represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, and the use thereof as a CDK7 inhibitor in the treatment of diseases or conditions related to abnormal activity of CDK7. Each group in general formula (I) is as defined in the description.
Inventors:
ZHU GUODONG (CN)
HU TAO (CN)
CHEN MEIJUN (CN)
HUO SHUHUA (CN)
LI JIAO (CN)
LI YUNFEI (CN)
HU TAO (CN)
CHEN MEIJUN (CN)
HUO SHUHUA (CN)
LI JIAO (CN)
LI YUNFEI (CN)
Application Number:
PCT/CN2023/126415
Publication Date:
May 02, 2024
Filing Date:
October 25, 2023
Export Citation:
Assignee:
TUOJIE BIOTECH SHANGHAI CO LTD (CN)
International Classes:
C07D407/04; A61K31/4375; A61K31/519; A61P35/00; C07D471/04
Domestic Patent References:
| WO2022064009A1 | 2022-03-31 | |||
| WO2016105528A2 | 2016-06-30 |
Foreign References:
| CN103635472A | 2014-03-12 |
Other References:
DATABASE Registry 6 July 2021 (2021-07-06), ANONYMOUS: "Pyrido[3,4-d]pyrimidine-7(6H)-c arboxamide, 2-[(4-fluorophenyl)amino]-N -[(1R)-1-[3-fluoro-4-(trifluoro methyl)phenyl]-2- (methylamino)ethyl]-5,8-dih ydro-", XP093166247, Database accession no. 2649602-21-9
DATABASE Registry 6 July 2021 (2021-07-06), ANONYMOUS: "Pyrido[3,4-d]pyrimidine-7(6H)-c arboxamide, N-[(1R)-1-(3-chloro-4-fluoro phenyl)-2-(methylamino)eth yl]-2-[(4- fluorophenyl)amino]-5,8-dih ydro-", XP093166250, Database accession no. 2649594-85-2
DATABASE Registry 6 July 2021 (2021-07-06), ANONYMOUS: "Pyrido[3,4-d]pyrimidine-7(6H)-c arboxamide, N-[(1R)-1-(3-chloro-4-fluoro phenyl)-2-(methylamino)eth yl]-2-[(4- fluorophenyl)amino]-5,8-dih ydro-", XP093166250, Database accession no. 2649594-85-2
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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