Title:
PLANTS CAPABLE OF METABOLIZING DRUGS AND UTILIZATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2000/017352
Kind Code:
A1
Abstract:
Transgenic plants capable of metabolizing drugs which are constructed by transferring a drug-metabolizing P450 molecular species into plants. These plants are capable of detoxifying and metabolizing foreign compounds such as drugs, poisons and environmental loads and endocrine disruptors including pesticides. Thus, they are highly useful when applied to field crops, etc. Also, a method for screening the drug-metabolizing P450 molecular species is provided.
Inventors:
OHKAWA HIDEO (JP)
OHKAWA YASUNOBU (JP)
OZAWA KENJIROU (JP)
HIROSE SAKIKO (JP)
OHKAWA YASUNOBU (JP)
OZAWA KENJIROU (JP)
HIROSE SAKIKO (JP)
Application Number:
PCT/JP1999/001573
Publication Date:
March 30, 2000
Filing Date:
March 26, 1999
Export Citation:
Assignee:
JP MINISTRY OF AGRICULTURE FOR (JP)
BIO ORIENTED TECHNOLOGY RESEAR (JP)
OHKAWA HIDEO (JP)
OHKAWA YASUNOBU (JP)
OZAWA KENJIROU (JP)
HIROSE SAKIKO (JP)
BIO ORIENTED TECHNOLOGY RESEAR (JP)
OHKAWA HIDEO (JP)
OHKAWA YASUNOBU (JP)
OZAWA KENJIROU (JP)
HIROSE SAKIKO (JP)
International Classes:
B09C1/10; C12N9/02; C12N15/12; C12N15/82; (IPC1-7): C12N15/12; C12N5/04; C12Q1/26; A01H1/00; A01H5/00; B09C1/00
Other References:
NORIAKI SHIOTA et al., "Herbicide-resistant tabacco plants expressing the fused enzyme between rat cytochrome P4501A1 (CYP1A1) and yeast NADPH-cytochrome P450 oxidoreductase", Plant Physiol. (1994) Vol. 106, No. 1, pages 17-23.
YOSHIROU IMAI et al., "P450-Sono tayouna kinou to ouyou", Protein, Nucleic Acid and Enzyme (1998), Vol. 43, No. 3, pages 203-215.
NORIAKI SHIOTA et al., "Metabolism of the herbicide chlortoluron in transgenic tabacco plants expressing the fused enzyme between rat cytochrome P4501A1 and yeast NADPH-cytochrome P450 oxidoreductase", Pesticide Biochemistry and Physiology (1996) Vol. 54, No. 3, pages 190-198.
YOSHIROU IMAI et al., "P450-Sono tayouna kinou to ouyou", Protein, Nucleic Acid and Enzyme (1998), Vol. 43, No. 3, pages 203-215.
NORIAKI SHIOTA et al., "Metabolism of the herbicide chlortoluron in transgenic tabacco plants expressing the fused enzyme between rat cytochrome P4501A1 and yeast NADPH-cytochrome P450 oxidoreductase", Pesticide Biochemistry and Physiology (1996) Vol. 54, No. 3, pages 190-198.
Attorney, Agent or Firm:
Shimizu, Hatsushi (Oroshi-machi Tsuchiura-shi Ibaraki, JP)
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