PLASMIN INHIBITOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Title:

PLASMIN INHIBITOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Document Type and Number:

WIPO Patent Application WO/2022/143911

Kind Code:

A1

Abstract:

A compound of formula (I) capable of inhibiting plasmin activity and delaying fibrinolysis, and having coagulation and hemostasis activity, a pharmaceutically acceptable salt thereof, a hydrate thereof, an isomer thereof, a prodrug thereof, and a mixture thereof, wherein X and R1 to R5 are as defined in the description.

Inventors:

YANG ANLE (CN)
JI SEN (CN)
WANG ZHI (CN)
WANG HAO (CN)
ZHANG DEWEI (CN)
WANG XIAO (CN)
SHEN HUAN (CN)
XIANG JIE (CN)
XIAN JIALING (CN)
WANG YAN (CN)
HU XIAO (CN)
ZHANG XIAODONG (CN)
TANG JUN (CN)

Application Number:

PCT/CN2021/143140

Publication Date:

July 07, 2022

Filing Date:

December 30, 2021

Export Citation:

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Assignee:

SCINNOHUB PHARMACEUTICAL CO LTD (CN)

International Classes:

C07D401/02; A61K31/4375; A61P7/04; C07D401/04; C07D401/12; C07D401/14; C07D471/00

Domestic Patent References:

WO2020108538A1	2020-06-04
WO2019063015A1	2019-04-04
WO2007002013A2	2007-01-04

Foreign References:

CN106458991A	2017-02-22
CN110684048A	2020-01-14
CN101115760A	2008-01-30

Other References:

TENGBOM LBLOMBACK MBERNTORP E, THROMB RES., vol. 135, no. 2, February 2015 (2015-02-01), pages 231 - 42
NG WJERATH AWASOWICZ M, ANAESTHESIOL INTENSIVE THER, vol. 47, no. 4, 2015, pages 339 - 50
TENGBORN LBLOMBACK MBERNTORP E, THROMB RES, vol. 135, no. 2, February 2015 (2015-02-01), pages 231 - 42

Attorney, Agent or Firm:

ZHONGZI LAW OFFICE (CN)

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