PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR - INST MED MOLECULAR DESIGN INC

Title:

PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR

Document Type and Number:

WIPO Patent Application WO/2005/026127

Kind Code:

A1

Abstract:

A medicine having plasminogen activator inhibitor-1 inhibiting activity, comprising as an active ingredient a compound of the general formula: (I) [wherein R¹ and R² are aromatic groups; W is a group selected from among linkage groups W-1 of the formulae: (wherein the left side bonds effect linkage with a carbon atom while the right side bonds effect linkage with a nitrogen atom; X is a sulfur atom or NH; Y is an oxygen atom or a sulfur atom; and R³ is a hydrocarbon group, hydroxyl or carboxyl); and Z is a single bond or a linkage group whose main chain has 1 to 3 atoms] or a salt thereof.

Inventors:

MUTO SUSUMU (JP)
KUBO ASAKO (JP)
ITAI AKIKO (JP)
SOTOME TOMOMI (JP)
YAMAGUCHI YOICHI (JP)

Application Number:

PCT/JP2004/013193

Publication Date:

March 24, 2005

Filing Date:

September 03, 2004

Export Citation:

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Assignee:

INST MED MOLECULAR DESIGN INC (JP)
MUTO SUSUMU (JP)
KUBO ASAKO (JP)
ITAI AKIKO (JP)
SOTOME TOMOMI (JP)
YAMAGUCHI YOICHI (JP)

International Classes:

A61P3/04; A61P7/02; A61P35/00; A61P43/00; C07D231/20; C07D277/20; C07D277/34; C07D277/36; C07D279/06; C07D405/06; C07D409/06; C07D417/06; C07D417/12; (IPC1-7): C07D231/22; C07D231/26; C07D231/36; C07D233/96; C07D277/34; C07D277/36; C07D401/06; C07D401/10; C07D401/12; C07D403/06; C07D409/12; C07D413/06; A61K31/4152; A61K31/4155; A61K31/4166; A61K31/427; A61K31/426; A61K31/4439; A61K31/4245; A61P7/02; A61P35/00; A61P3/04; A61P43/00

Domestic Patent References:

WO2000032598A1	2000-06-08
WO2001057006A1	2001-08-09
WO2004024061A2	2004-03-25

Foreign References:

JPH0895208A	1996-04-12
JPS60156387A	1985-08-16
DE1119436B	1961-12-14

Other References: