Title:
PLAU AND/OR PLAUR GENE-MODIFIED NON-HUMAN ANIMAL
Document Type and Number:
WIPO Patent Application WO/2023/236958
Kind Code:
A1
Abstract:
Provided are a non-human animal expressing a human or chimeric (e.g., humanized) PLAU and/or PLAUR protein and a method for using same.
Inventors:
LV RUILI (CN)
WANG LINLIN (CN)
SHEN ZHIYUAN (CN)
WANG LINLIN (CN)
SHEN ZHIYUAN (CN)
Application Number:
PCT/CN2023/098641
Publication Date:
December 14, 2023
Filing Date:
June 06, 2023
Export Citation:
Assignee:
BIOCYTOGEN PHARMACEUTICALS BEIJING CO LTD (CN)
International Classes:
C07K16/28; A01K67/027; C07K14/705; C12N15/09; C12N15/85; G01N33/50
Domestic Patent References:
| WO2021263146A2 | 2021-12-30 |
Foreign References:
| CN111837036A | 2020-10-27 | |||
| US20110023149A1 | 2011-01-27 | |||
| CN111073907A | 2020-04-28 | |||
| CN111118019A | 2020-05-08 | |||
| CN111172190A | 2020-05-19 |
Other References:
DATABASE Protein 8 May 2022 (2022-05-08), ANONYMOUS : "urokinase plasminogen activator surface receptor isoform 1 precursor [Homo sapiens]", XP093115054, retrieved from NCBI Database accession no. NP_002650.1
DATABASE Protein 8 May 2022 (2022-05-08), ANONYMOUS : "urokinase-type plasminogen activator isoform 1 preproprotein [Homo sapiens]", XP093115056, retrieved from NCBI Database accession no. NP_002649.2
MINAEI ELAHE, MUELLER SIMON A., ASHFORD BRUCE, THIND AMARINDER SINGH, MITCHELL JENNY, PERRY JAY R., GENENGER BENJAMIN, CLARK JONAT: "Cancer Progression Gene Expression Profiling Identifies the Urokinase Plasminogen Activator Receptor as a Biomarker of Metastasis in Cutaneous Squamous Cell Carcinoma", FRONTIERS IN ONCOLOGY, FRONTIERS RESEARCH FOUNDATION, CH, vol. 12, CH , XP093115058, ISSN: 2234-943X, DOI: 10.3389/fonc.2022.835929
DATABASE Protein 8 May 2022 (2022-05-08), ANONYMOUS : "urokinase-type plasminogen activator isoform 1 preproprotein [Homo sapiens]", XP093115056, retrieved from NCBI Database accession no. NP_002649.2
MINAEI ELAHE, MUELLER SIMON A., ASHFORD BRUCE, THIND AMARINDER SINGH, MITCHELL JENNY, PERRY JAY R., GENENGER BENJAMIN, CLARK JONAT: "Cancer Progression Gene Expression Profiling Identifies the Urokinase Plasminogen Activator Receptor as a Biomarker of Metastasis in Cutaneous Squamous Cell Carcinoma", FRONTIERS IN ONCOLOGY, FRONTIERS RESEARCH FOUNDATION, CH, vol. 12, CH , XP093115058, ISSN: 2234-943X, DOI: 10.3389/fonc.2022.835929
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