Title:
PLEUROMUTILIN DERIVATIVE WITH AMINO SIDE CHAIN, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/115691
Kind Code:
A1
Abstract:
Provided are a pleuromutilin derivative with an amino side chain, and a preparation method therefor and the use thereof. The pleuromutilin derivative is a compound having a structure as shown in formula 2 or a pharmaceutically acceptable salt thereof, and a solvate, enantiomer, diastereoisomer, tautomer or a mixture thereof in any ratio. The pleuromutilin derivative has good antibacterial activity and is suitable for use as an antibacterial drug against systemic infection of animals or humans.
Inventors:
LIU YAHONG (CN)
FANG HANQING (CN)
TANG YOUZHI (CN)
JIN ZHEN (CN)
FANG HANQING (CN)
TANG YOUZHI (CN)
JIN ZHEN (CN)
Application Number:
PCT/CN2022/077796
Publication Date:
June 29, 2023
Filing Date:
February 25, 2022
Export Citation:
Assignee:
UNIV SOUTH CHINA AGRICULT (CN)
International Classes:
C07C227/08; A61K31/223; A61P31/04; C07C229/18
Foreign References:
| EP2014640A1 | 2009-01-14 | |||
| CN111574395A | 2020-08-25 | |||
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| CN103265442A | 2013-08-28 | |||
| CN109152932A | 2019-01-04 | |||
| CN106543054A | 2017-03-29 | |||
| CN109195608A | 2019-01-11 | |||
| CN110467603A | 2019-11-19 | |||
| CN110372615A | 2019-10-25 | |||
| CN103910663A | 2014-07-09 | |||
| CN113149929A | 2021-07-23 | |||
| CN106565564A | 2017-04-19 |
Other References:
FANG HAN-QING, JIE ZENG , SHOU-KAI WANG , XIAO WANG , FANG CHEN , BO LI , JIE LIU , ZHEN JIN , YA-HONG LIU , YOU-ZHI TANG: "Discovery of Novel Pleuromutilin Derivatives as Potent Antibacterial Agents for the Treatment of MRSA Infection", MOLECULES, vol. 27, no. 3, 1 January 2020 (2020-01-01), pages 1 - 22, XP093073969, DOI: 10.3390/molecules27030931
DONG YING-JIE; MENG ZI-HUI; MI YAN-QING; ZHANG CHUN; CUI ZHI-HAO; WANG PENG; XU ZHI-BIN: "Synthesis of novel pleuromutilin derivatives. Part 1: Preliminary studies of antituberculosis activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 25, no. 8, 17 February 2015 (2015-02-17), Amsterdam NL , pages 1799 - 1803, XP029155103, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2015.02.023
DONG YING-JIE; MENG ZI-HUI; MI YAN-QING; ZHANG CHUN; CUI ZHI-HAO; WANG PENG; XU ZHI-BIN: "Synthesis of novel pleuromutilin derivatives. Part 1: Preliminary studies of antituberculosis activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 25, no. 8, 17 February 2015 (2015-02-17), Amsterdam NL , pages 1799 - 1803, XP029155103, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2015.02.023
Attorney, Agent or Firm:
SHENZHEN ELSON PATENT AGENT FIRM (GENERAL PARTNERSHIP) (CN)
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