Title:
PNEUMOCOCCAL SURFACE PROTEINS
Document Type and Number:
WIPO Patent Application WO/2020/203731
Kind Code:
A1
Abstract:
The present invention provides D39-derived mutant PspA that does not undergo deamination and maintains molecular stability even at near-neutral pH. Specifically, the present invention is the following protein (a) or (b). (a) A protein that includes the amino acid sequence represented by sequence no. 2 and that has pneumococcus vaccine antigenic activity, and a protein substantially the same as said protein; and (b) a protein that includes a portion of the amino acid sequence represented by sequence no. 2, said portion including aspartic acid at position 254, and that has pneumococcus vaccine antigenic activity, and a protein substantially the same as said protein.
Inventors:
YUKI YOSHIKAZU (JP)
NAKAHASHI RIKA (JP)
KIYONO HIROSHI (JP)
NAKAHASHI RIKA (JP)
KIYONO HIROSHI (JP)
Application Number:
PCT/JP2020/013929
Publication Date:
October 08, 2020
Filing Date:
March 27, 2020
Export Citation:
Assignee:
UNIV TOKYO (JP)
HANAVAX INC (JP)
HANAVAX INC (JP)
International Classes:
A61K39/09; A61P11/00; A61P37/04; C07K14/315; C12N15/31
Domestic Patent References:
| WO2014045621A1 | 2014-03-27 | |||
| WO2005113584A1 | 2005-12-01 | |||
| WO2018102774A2 | 2018-06-07 | |||
| WO2000012564A1 | 2000-03-09 |
Foreign References:
| JP2015151375A | 2015-08-24 |
Other References:
NOGUCHI, SHUJI: "Isomerization of Aspartic Acid in Protein", NIHON KESSHO GAKKAISHI = JOURNAL OF THE CRYSTALLOGRAPHIC SOCIETY OF JAPAN, vol. 40, no. 4, 1998, pages 272 - 278, XP009531469, ISSN: 0369-4585, DOI: 10.5940/jcrsj.40.272
BERRY ET AL., INFECT IMMUN, vol. 57, 1989, pages 2037 - 2042
MCDANIEL ET AL., J EXP MED, vol. 165, 1987, pages 381 - 394
BRILES ET AL., INFECT IMMUN, vol. 68, 2000, pages 796 - 800
NGUYEN ET AL., VACCINE, vol. 29, 2011, pages 5731 - 5739
MCCOOL ET AL., J EXP MED, vol. 195, 2002, pages 359 - 365
"GenBank", Database accession no. ABJ54172
BERRY ET AL., INFECT IMMUN, vol. 57, 1989, pages 2037 - 2042
MCDANIEL ET AL., J EXP MED, vol. 165, 1987, pages 381 - 394
BRILES ET AL., INFECT IMMUN, vol. 68, 2000, pages 796 - 800
NGUYEN ET AL., VACCINE, vol. 29, 2011, pages 5731 - 5739
MCCOOL ET AL., J EXP MED, vol. 195, 2002, pages 359 - 365
"GenBank", Database accession no. ABJ54172
Attorney, Agent or Firm:
OKUHARA Koji et al. (JP)
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