Title:
POLYAMIDE COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/059331
Kind Code:
A1
Abstract:
The present invention relates to a polyamide compound and a use thereof; specifically, the present invention relates to a type of polyamide compound (which preferably contains one or more amide bonds formed by the condensation of same or different L-amino acids or D-amino acids), or stereoisomers thereof, polymorphs thereof, solvates thereof, or metabolites thereof, prodrugs thereof or pharmaceutically acceptable salts or esters thereof, or pharmaceutical compositions thereof, as well as a method for preparing the polyamide compound and a use thereof in the prevention or treatment of diseases associated with a κ-opioid receptor. The polyamide compound of the present invention has excellent κ-opioid receptor agonistic activities and hydrophilic ability, thus having a lesser ability of penetrating the blood-brain barrier and a lowered capacity for entering the brain. The compound of the present invention has higher selectivity for a κ-opioid receptor, lowered addictiveness, improved pharmacokinetic properties, and improved safety (lower toxicity and/or fewer side effects, good patient compliance, and/or a lesser propensity for developing tolerance, among other excellent medicinal properties).
Inventors:
CAI JIAQIANG (CN)
TIAN QIANG (CN)
ZHAO MINGLIANG (CN)
ZENG HONG (CN)
SONG HONGMEI (CN)
YU NAN (CN)
DENG HUA (CN)
ZHONG WEI (CN)
YANG LONG (CN)
WU LEI (CN)
HUANG HAITAO (CN)
WU YONGYONG (CN)
SU DONGHAI (CN)
ZHOU XIN (CN)
TAN YUTING (CN)
WANG LICHUN (CN)
WANG JINGYI (CN)
TIAN QIANG (CN)
ZHAO MINGLIANG (CN)
ZENG HONG (CN)
SONG HONGMEI (CN)
YU NAN (CN)
DENG HUA (CN)
ZHONG WEI (CN)
YANG LONG (CN)
WU LEI (CN)
HUANG HAITAO (CN)
WU YONGYONG (CN)
SU DONGHAI (CN)
ZHOU XIN (CN)
TAN YUTING (CN)
WANG LICHUN (CN)
WANG JINGYI (CN)
Application Number:
PCT/CN2017/103027
Publication Date:
April 05, 2018
Filing Date:
September 22, 2017
Export Citation:
Assignee:
SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
C07K7/06; A61K38/08; A61P1/00; A61P3/12; A61P7/10; A61P11/14; A61P17/00; A61P27/06; A61P29/00
Foreign References:
| CN1665501A | 2005-09-07 | |||
| CN107098871A | 2017-08-29 |
Other References:
See also references of EP 3521301A4
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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