Title:
POLYCYCLIC COMPOUND, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/024188
Kind Code:
A1
Abstract:
Provided are a polycyclic compound and a manufacturing method, pharmaceutical composition, and application thereof. The structure of the polycyclic compound and an isomer, prodrug, solvate, hydrate, stable isotopic derivative, or pharmaceutically acceptable salt thereof are represented by formula (I). The polycyclic compound has an excellent inhibitory effect against ID01, and can effectively treat, mitigate and/or prevent various diseases caused by immunosuppression, including an autoimmune disease caused by a tumor or viral infection.
Inventors:
CHEN SHOUJUN (CN)
LI QUN (CN)
LIU SHENGYANG (CN)
GUO HONGLI (CN)
LIU FENGTAO (CN)
LI QUN (CN)
LIU SHENGYANG (CN)
GUO HONGLI (CN)
LIU FENGTAO (CN)
Application Number:
PCT/CN2017/095396
Publication Date:
February 08, 2018
Filing Date:
August 01, 2017
Export Citation:
Assignee:
SHANGHAI DE NOVO PHARMATECH CO LTD (CN)
International Classes:
A61K31/40; C07D249/06; A61K31/41; A61P31/00; A61P35/00; A61P37/02; C07D261/18; C07D271/08; C07D277/56; C07D307/68
Domestic Patent References:
| WO2011005052A2 | 2011-01-13 | |||
| WO2016073774A2 | 2016-05-12 |
Other References:
SEO, H.J. ET AL.: "Design and Synthesis of Novel Arylpiperazine Derivatives Containing the Imidazole Core Targeting 5-HT2A Receptor and 5-HT Transporter", JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, 8 August 2011 (2011-08-08), pages 6305 - 6318, XP055461002
CHEMICAL ABSTRACTS, 30 April 2014, Columbus, Ohio, US; abstract no. RN1594335-16-6, "RN1594335-16-6"
CHEMICAL ABSTRACTS, 30 April 2014, Columbus, Ohio, US; abstract no. RN1593550-87-8
CHEMICAL ABSTRACTS, 14 April 2014, Columbus, Ohio, US; abstract no. RN1584366-54-0
CHEMICAL ABSTRACTS, 30 April 2014, Columbus, Ohio, US; abstract no. RN1594335-16-6, "RN1594335-16-6"
CHEMICAL ABSTRACTS, 30 April 2014, Columbus, Ohio, US; abstract no. RN1593550-87-8
CHEMICAL ABSTRACTS, 14 April 2014, Columbus, Ohio, US; abstract no. RN1584366-54-0
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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