Title:
POLYCYCLIC COMPOUNDS AS KRAS G12D INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2023/198078
Kind Code:
A1
Abstract:
The present invention provides compounds as KRAS G12D inhibitors. Specifically, the present invention provides compounds having a structure represented by formula (I), or optical isomers, pharmaceutically acceptable salts, prodrugs, deuterated derivatives, hydrates, and solvates thereof. The compounds can be used for treating or preventing diseases or conditions related to the activity or expression quantity of KRAS G12D.
Inventors:
ZHANG HANCHENG (CN)
CAI CONGCONG (CN)
CAI CONGCONG (CN)
Application Number:
PCT/CN2023/087690
Publication Date:
October 19, 2023
Filing Date:
April 11, 2023
Export Citation:
Assignee:
HANGZHOU INNOGATE PHARMA CO LTD (CN)
International Classes:
A61K31/517; C07D487/00; A61K31/519; A61P35/00; A61P35/02; C07D487/04; C07D487/14; C07D491/052; C07D519/00
Domestic Patent References:
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| WO2021248090A1 | 2021-12-09 | |||
| WO2022042630A1 | 2022-03-03 | |||
| WO2020146613A1 | 2020-07-16 | |||
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| WO2022228568A1 | 2022-11-03 | |||
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Foreign References:
| US20200331911A1 | 2020-10-22 | |||
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| CN114615981A | 2022-06-10 |
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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