Title:
POLYCYCLIC RING-FUSED DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/094163
Kind Code:
A1
Abstract:
Disclosed are a polycyclic ring-fused derivative, a preparation method therefor, and use thereof. In particular, disclosed are a compound represented by general formula (I-2-1), a preparation method therefor, a pharmaceutical composition comprising the compound, and use thereof as a regulator in the treatment of a cancer-related disease. Substituents in general formula (I-2-1) are as defined in the specification.
Inventors:
XIAO HUALING (CN)
SU YIDONG (CN)
YU WENSHENG (CN)
FAN BOBO (CN)
LIU YONG (CN)
SU YIDONG (CN)
YU WENSHENG (CN)
FAN BOBO (CN)
LIU YONG (CN)
Application Number:
PCT/CN2023/129556
Publication Date:
May 10, 2024
Filing Date:
November 03, 2023
Export Citation:
Assignee:
SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
International Classes:
C07D471/04; A61K31/4738; A61P35/00; A61P37/00; C07D403/12; C07D519/06
Domestic Patent References:
| WO2023098880A1 | 2023-06-08 | |||
| WO2021222556A1 | 2021-11-04 |
Other References:
WROBEL J, ET AL.: "SYNTHESES OF TOLRESTAT ANALOGUES CONTAINING ADDITIONAL SUBSTITUENTSIN THE RING AND THEIR EVALUATION AS ALDOSE REDUCTASE INHIBITORS IDENTIFICATION OF POTENT, ORALLY ACTIVE 2-FLUORO DERIVATIVES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 34, no. 08., 1 August 1991 (1991-08-01), US , pages 2504 - 2520, XP000567039, ISSN: 0022-2623, DOI: 10.1021/jm00112a029
BING ZHOU; YAXI YANG; JINGJING SHI; HUIJIN FENG; YUANCHAO LI: "Rhodium‐Catalyzed Synthesis of Amides from Aldehydes and Azides by Chelation‐Assisted CH Bond Activation", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY & SONS, INC, DE, vol. 19, no. 32, 27 June 2013 (2013-06-27), DE, pages 10511 - 10515, XP071837351, ISSN: 0947-6539, DOI: 10.1002/chem.201301168
BING ZHOU; YAXI YANG; JINGJING SHI; HUIJIN FENG; YUANCHAO LI: "Rhodium‐Catalyzed Synthesis of Amides from Aldehydes and Azides by Chelation‐Assisted CH Bond Activation", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY & SONS, INC, DE, vol. 19, no. 32, 27 June 2013 (2013-06-27), DE, pages 10511 - 10515, XP071837351, ISSN: 0947-6539, DOI: 10.1002/chem.201301168
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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