This invention relates to a process for the manufacture of a polyester comprising filament material suitable for surgical application, as such or in woven, braided or knitted form, as well as reinforcing beads. The invention further relates to a synthetic surgical material that is biocompatible with a patient and is biodegradable.

The invented process of spinning a polyester material in the presence of a certain additive can be used in the production of highly fibrillated sutures, which due to their fibrillation exhibit a good resorption rate and flexibility important for handling the suture and tying the knot.

Regular structurization at the fibre surf ce, created in the present spinningprocess, and preserved in the fibre even after hot- ι drawing, provides to the fibre a high knot strength.

There exist a number of commercial biocompatible and biodegradable sutures based on polyglycolide (Dexon) , copolymer of lactide and glycolide (Vicryl) , or lactone of hydroxyethyl glycolic acid (PDS) . These well known materials are convenient to handle, and have the required rate of bioresorption. However there still exists a need for new biocompatible and biodegradable suture materials. As follows from literature data, polylactide fibers have already been produced, but the rate of degradation of these fibers is too low as compared with that of Vicryl, Dexon or PDS sutures.

While Vicryl, Dexon and PDS sutures respectively disappear after about 90, 120 and 180 days from implantation, the polylactide sutures are not resorbed until after about 8 to 17 months from implantation.

Thus although polylactide is a biocompatible, biodegradable and fiberforming polymer, the polylactide sutures have not so far found practical application in surgery.

It is an object of the present invention to provide sutures with adequate tensile strength, high dimensional stability and a rate of

hvdrolysis comparable- to those of Vicryl, Dexon or PDS sutures. It is another object, of the present invention, to provide fibers which have a flexibility higher ^* than those produced according- to the standard methods, yet having ^* high ^* tensile strength and modulus. It is a further object cf. the present invention to provide su ^* εurss having a knot strength higher than that of fibers produced by standard spinning procedures. These and. other objects -are attained by filament material produced by dry- ^* - orwet-spinπ±ng a spinning mixture comprising a polyester material and an addi ive, particularly a polyurethane material. When- wet-spinning a. coagulant material is needed. Preferred polyester materials are poly (I.-lactide) , (PL A) , poly(dL-lactide) (PdL A) , and combinations thereof:, having a viscosity-average molecular weight of at least about 3 x 10 and preferably above 5.0 x 10 Kg/kmol, as calcula ^t ed according- to the foraule: [a] = 5.4S s 10 M ^* , for a viscosity measured at 25°C in trichlormethane.

Examples of additives other than the polyurethane material which, can be used in preparing the fil-ament material of this invention, are glycolid , lactide, camphor, benzoic acid-2-hydroxyacetate, hexamethylbenzene, 1,2-cyciohexandione and other low-molecular weight organic- compounds which are preferably soluble in trichlαrmethane and/or diσhlormethane and ethanol, and have a melting campe ture in the range of 40 to 130°C.

Polyurethane is a preferred additive in the spinning mixture, and as such may be used a polyester urethane based on hexamethyiene diisocyanata, 1 ,4-butanedioi and a copoiymer of lactic acid and ethylene glycol, diethylene glycol or tetramethylene glycol; hexamethyiene diisocyanate, 2,4,β-tris(diaethylaiainomethyl)phenol and copoiymer of lactic ^* acid and diethylene- glycol, erhylane glycol, or tetramethylene glycol, a polyester urethane based on hexamethyiene diisocyanata, trimethyiαl propane and a- copoiymer of polylactic acid and tetramethylene glycol or a polyester urethane based on 4, '-diohenyi- ethane diisocyanata, 1,4-butanediol and poiyts-crame ^* chylene adioata. The concentration of the additive in the polylactide material mav be in the range of 1 to 45 % by weight.

Filament material prepared from this kind of polylactide/ additive mixtures are formed by dry-spinning the polymer from a solution

in a well dissolving material, in particular in dichloromethane and/or trichloromethane at room temperature through a spinneret. The filament material obtained is thereafter, according to a particularly preferred embodiment of the process according to the invention, subjected to a hot-drawing operation applying a drawing ratio within a wide range, particularly up to about 25.

The resulting oriented filaments are strong and owing to their regularly structurized surface form strong knots.

Owing to extensive fibrillation by virtue of using an additive, the fibres are flexible and easy to handle upon suturing or knotting and hydrolysa much faster than the standard polylactide fibers.

The invented fibers, such as the polylactide comprising fibers, exhibit very little shrinkage when heated at 37°C in water for 30 hours, namely, about 1 to 5 percent of their initial length. The invented spinning process avoids degradation of the polymer during extrusion, resulting in fibers of higher tensile strength.

It is recommendable that ethylene oxide is applied for sterilization of the fibers, for example polylactide comprising fibers , as high-energy radiation may result in crosslinking and chain scission and some decrease in tensile strength.

After sterilization with ethylene oxide, the sxi ures in

-A sealed packages, are subjected to a vacuum of 10 Torr at 70°C for 1 hour. This avoids absorption of sterilizing gas in the sutures.

The filaments according to the present invention have a good tensile strength of at least 0.4G?a, preferably 0.7 G?A. Some have tensile strengths as high as 0.8 to 1.0 GPa. The invented fibers are resorbed as to 50% after about 150 days, which rate of hydrolysis is comparable to that of PDS fibers with comparable thickness and strength. The filaments according to the invention, such as the poly¬ lactide comprising fibers, may be woven, braided, knitted or used as monofilaments of general surgical application, may be used as reinforcing beads for the construction of biodegradable tracheal or vascular prostheses, especially for by-pass systems. The polymeric material, in particular when being PLLA and/or PdLLA, which can be converted to filaments particularly by dry-spinning may be present in a spinning

^•a b¬

solution, -and this in a concentration of 10 to 40% by weight in dichlorσ- methane and/or trichloro ethane, as these two solvents easily dissolve the polylactide with the above viscosity-average molecular weight of about 3 x 10 Kg/k ol at room temperature. Spinning polylactide fibers from a solution with a concentration in the range of 10 to 40 % by weight provides a monofilament of reasonable tensile strength, which is in addition regularly structurized due to the melt fracture as schematically shown in the accompanying drawing as obtained (drawing ratio λ= 0) and after hot-drawing at drawing ratios λ of 6, 10 and 20, respectively. Even hot-drawing at high draw ratios does not completely remove the surface structure but results in an extension of the pitch of the helix structure.

The diameter of the resulting fibre will generally be in the

-4 range of 0.3 to 1 x 10 m. Preferred monofilaments have a diameter of about 0.4 to1 x 10~ m.

Spinnerets having orifice sizes of 0.2 to 1 mm nd a length of the capillary of 10 mm are suitable for spinning the onofilaments.

In dry-spinning from dichlormethane or trichlormethane solutions, the solution is extruded at room temperature at ^' which the solvent evaporates ■ slowly. A preferred polymer concentration is 15-25, in particular about

20 % by weight.

The filament is extruded at a speed in the range of 0.02 to

2 mm/min. This gives no orientation to the fibre as spun. After spinning the polylactide fibers are hot-drawn at a temperature in the range of 45 to 200°C, preferably at 110, 170, 180 or 200°C, which temperature depends on the additive concentration in the polymer and the melting temperature of the additive.

The draw ratio λ may be up to 25, preferably 14 to 18.

Take-up speed may be in the range of 0.2 to 1 cm.sec~ with a strain rate in the range of 10 sec.

The hot-drawing of fibers may be carried our in an electric tube-furnace with a length of 60 cm under a dry, oxygen-free atmosphere.

Hot-drawing at temperatures above 120°C may reduce the molecular weight of the starting polymer by 1 - 2 percent. The filament can be colored- ^" by adding an inert material, e.g. Cosmetic Violet No. 2, to the solvent before reDaration of the

spinning- solution ^* .

The invention is illustrated in and by the following examples :

ΞXAMP 2 I

Filaments, with a regularly structurized surface and having a diameter of 0.44 x 10 m, a. tensile strength of 1 GPa, a modulus of 12 GPa, a strength, of ^* square knot of 0.6 GPa. and an elongation at break or 13 % were prepared by spinning- poly (L-lactide) from a 20 wt % solution in trichlόromethane a room temperature.

The pol (L-lactide) had a viscosity-average molecular weight of δ.O x 10°. The fibre as spun was. hot-drawn at 200°C to a draw ratio of 20. SXAMPLΞ π

Filaments with, a- regularly ^* structurized surface and having- a

-4 diameter of 0.6 x ^** 10 m, a tensile strength of 0.3 GPa, a modulus of 9 GPa, a strength of a square knot of 0.5 GPa and an elongation at break of 17 % were prepared by spinning ^* poly(L-lactide) which contained 10 % by weight of camphor, from a 20 wt % solution in trichloromethane at room -amperature. 'The poly(L-lactide) had a viscosity-average molecular weight of β.O x 10 . Tha fibre was drawn at 1S0°C to a draw ratio of 4. After ^* hot-drawing the filaments were extracted in ethanol for 4 hours. No additive was present in the- fibre after extraction. The filaments obtained turned out to have a highly ibrillatad structur . ΞXA PLΞ III

Filaments with a regularly structurized surface and having a diameter ^* of 0.7 x 10 m, a tensile strength of 0.65 GPa, a modulus of 3 GPa, a strength of a square knot of 0.45 GPa and an elongation at break,of 19 % ^• were prepared- by spinning ^* poly (L-lactide) containing 5 % by weight of polyester urethane from ^* an 13 wt % solution in an hydrous trichlormethane. The pol (L-lactide) had a viscosity-average molecular weight of 4.0 x 10 . The fibre was drawn at 150°C co a draw ratio of

24. The pol (L-lactide)/polyester urethane monofilament so obtained has a highly fibrill ad. structure. EXAMPLE IV

Highly fi-brillatad filaments having a diameter of 0.6 x 10~ ^' m, a tensile strength at break of 0.7 GPa were kept in water at 37°C for 10 to 200 days. After about 150 days ^* the filaments were hydrolysed as

-θ-

to 50 %. This rate of hydrolysis is comparable to that of PDS filaments of similar strangrh and thickness.

OMPI