POLYETHYLENE GLYCOL-MODIFIED IL-21 DERIVATIVE AND USE THEREOF

Title:

POLYETHYLENE GLYCOL-MODIFIED IL-21 DERIVATIVE AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2024/046280

Kind Code:

A1

Abstract:

Provided are a polyethylene glycol-modified IL-21 derivative and the use thereof. By analyzing the structure of IL-21, under the condition that the overall structure of IL-21 is not affected, specific sites in IL-21 are mutated into cysteine, and then the suitable PEG molecules are connected to the mutated cysteine on IL-21 by means of coupling via sulfydryl. The plasma half-life of PEG-modified IL-21 is prolonged, and the PEG-modified IL-21 has excellent dose-dependent anti-tumor drug effect. In addition, the PEG-modified IL-21 has better water solubility, which is beneficial to the formula of a preparation of a drug. Compared with other long-acting IL-21 fusion proteins, which need to be expressed in mammalian cells, the IL-21 skeleton protein used by PEG modification is obtained by means of expression in Escherichia coli, denaturation and renaturation and purification, which has the industrialization advantages of low cost and high yield.

More Like This:

JP3173001	INDUSTRIAL APPLICABILITY Word recognition in a speech recognition system using a data organizing word template.
JP2711182	INDUSTRIAL APPLICABILITY: A method for inhibiting HIV replication using IL-4.
WO/1996/040267	THE REGULATION OF SYSTEMIC IMMUNE RESPONSES UTILIZING CYTOKINES AND ANTIGENS

Inventors:

ZHOU JIAJIE (CN)
ZHANG QI (CN)
WANG LICUI (CN)
ZHANG TIANFU (CN)
ZHAO YANYU (CN)
TAN WEI (CN)
WANG GUOYONG (CN)
WANG YAYUAN (CN)
ZHANG QIULEI (CN)
ZHANG JIANJUN (CN)
LIU YI (CN)
JIN XIULI (CN)
HUANG YINGZI (CN)
GAO XIANG (CN)
ZHANG WEI (CN)

Application Number:

PCT/CN2023/115300

Publication Date:

March 07, 2024

Filing Date:

August 28, 2023

Export Citation:

Click for automatic bibliography generation Help

Assignee:

LETO LABORATORIES CO LTD (CN)

International Classes:

C07K14/54; A61K47/60

Domestic Patent References:

WO2022135469A1	2022-06-30
WO2008074863A1	2008-06-26
WO2010076339A1	2010-07-08

Foreign References:

CN111164100A	2020-05-15
CN101189024A	2008-05-28
CN102516386A	2012-06-27
CN107698682A	2018-02-16
US20060228331A1	2006-10-12

Attorney, Agent or Firm:

BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)

Download PDF:

View/Download PDF PDF Help

Previous Patent: POLYMORPH OF MAO-B INHIBITOR PRODRUG, AND PREPARATION METHOD THEREFOR AND USE THEREOF

Next Patent: LIGHT-EMITTING DEVICE, MANUFACTURING METHOD THEREFOR AND DISPLAY PANEL