POLYGLYCEROL AND LACTOSE COMPOSITIONS FOR THE PROTECTION OF LIVING SYSTEMS FROM STATES OF REDUCED METABOLISM

Title:

POLYGLYCEROL AND LACTOSE COMPOSITIONS FOR THE PROTECTION OF LIVING SYSTEMS FROM STATES OF REDUCED METABOLISM

Document Type and Number:

WIPO Patent Application WO2003065801

Kind Code:

A3

Abstract:

Polyglycerol, lactose, and a combination of polyglycerol and lactose are effective at preserving cells, tissues, and organs from damage due to hypothermic, ischemic, or other metabolic impairment, and a mixture of polyglycerol plus lactose is particularly useful for the hypothermic storage of cells, tissues, and organs. The mixture of polyglycerol and lactose can be further improved by the addition of chondroitin sulfate, chlorpromazine, calcium, citrate, glutathione, adenine, glucose, magnesium, and a pH buffer.

Inventors:

FAHY GREG (US)
WU JU (US)

Application Number:

PCT/US2003/002939

Publication Date:

February 26, 2004

Filing Date:

January 31, 2003

Export Citation:

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Assignee:

21ST CENTURY MEDICINE INC (US)
FAHY GREG (US)
WU JU (US)

International Classes:

A01N1/02; C09K3/18; C09K5/20; (IPC1-7): A01N1/02

Foreign References:

US6194137B1

2001-02-27

Other References:

KLEBE ET AL.: "Identification of new cryptoprotective agents for cultured mammalian cells", IN VITRO, vol. 19, no. 3, PART 1, March 1983 (1983-03-01), pages 167 - 170, XP002129064

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