POLYMER-BASED MULTI-ELEMENT SURFACE-ENHANCED RAMAN DETECTION SUBSTRATE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN CANCER DIAGNOSIS

Title:

POLYMER-BASED MULTI-ELEMENT SURFACE-ENHANCED RAMAN DETECTION SUBSTRATE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN CANCER DIAGNOSIS

Document Type and Number:

WIPO Patent Application WO/2022/134459

Kind Code:

A1

Abstract:

A polymer-based multi-element surface-enhanced Raman detection substrate, a preparation method therefor and an application thereof in cancer diagnosis. The substrate comprises a polymer substrate (110), a resin layer (120), a noble metal thin film layer (130), a metal oxide thin film layer (140), and three-dimensional island ultrathin silver films (150) which are sequentially stacked to each other. An island structure in each three-dimensional island ultrathin silver film (150) is a uniformly distributed nanostructure, and the thickness of each three-dimensional island ultrathin silver film (150) ranges from 1.5 to 20 nm. The flexible surface-enhanced Raman scattering substrate has high sensitivity, good consistency and high flux, and can be used for early diagnosis of cancer.

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Inventors:

DU LUTAO (CN)
ZHANG CHENGPENG (CN)
CHEN SHUAI (CN)
LI JUAN (CN)
LI YANRU (CN)
LI PEILONG (CN)
WANG JILAI (CN)
SHI ZHENYU (CN)
WANG CHUANXIN (CN)

Application Number:

PCT/CN2021/096128

Publication Date:

June 30, 2022

Filing Date:

May 26, 2021

Export Citation:

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Assignee:

UNIV SHANDONG (CN)

International Classes:

G01N21/65

Foreign References:

CN112683879A	2021-04-20
CN110129756A	2019-08-16
CN110044872A	2019-07-23
CN110044869A	2019-07-23
CN110220881A	2019-09-10
CN110314830A	2019-10-11
CN104698515A	2015-06-10
CN110501324A	2019-11-26
US7391511B1	2008-06-24

Other References:

ZHANG CHENGPENG, YI PEIYUN, PENG LINFA, LAI XINMIN, CHEN JIE, HUANG MEIZHEN, NI JUN: "Continuous fabrication of nanostructure arrays for flexible surface enhanced Raman scattering substrate", SCIENTIFIC REPORTS, vol. 7, no. 1, 1 February 2017 (2017-02-01), XP055946289, DOI: 10.1038/srep39814

Attorney, Agent or Firm:

JINAN SHENGDA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)

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