Title:
POLYMER, IN VIVO DEGRADABLE MATERIAL, AND USE
Document Type and Number:
WIPO Patent Application WO/2000/071602
Kind Code:
A1
Abstract:
A polymer having a satisfactory balance between in vivo degradability and satisfactory mechanical properties, which is an A?1¿BA?2¿ type polymer comprising a segment A?1¿ and a segment A?2¿ each having a modified amino acid and a segment B consisting of polyethylene glycol with a number-average molecular weight of 8,000 or higher bonded at one end to the segment A?1¿ and at the other end to the segment A?2¿, and has a number-average molecular weight of 10,000 to 600,000; an in vivo degradable material which comprises the polymer; and a film for preventing tissue adhesion, an artificial dura mater, a suture, an implant preparation, or a sustained-release drug base each comprising the degradable material.
Inventors:
OGURA ATSUHIKO (JP)
IWASAKI HIROSHI (JP)
TANAKA SHINJI (JP)
IWASAKI HIROSHI (JP)
TANAKA SHINJI (JP)
Application Number:
PCT/JP2000/003181
Publication Date:
November 30, 2000
Filing Date:
May 18, 2000
Export Citation:
Assignee:
NOF CORP (JP)
OGURA ATSUHIKO (JP)
IWASAKI HIROSHI (JP)
TANAKA SHINJI (JP)
OGURA ATSUHIKO (JP)
IWASAKI HIROSHI (JP)
TANAKA SHINJI (JP)
International Classes:
A61L17/10; A61L27/14; A61L27/16; A61L31/04; C08G65/333; C08G69/44; C08L71/02; (IPC1-7): C08G69/44; C08G81/00; C08G65/333; A61L27/14; A61L17/10
Domestic Patent References:
| WO1992000748A1 | 1992-01-23 | |||
| WO1992016555A1 | 1992-10-01 |
Foreign References:
| EP0397307A2 | 1990-11-14 | |||
| JPS63132939A | 1988-06-04 |
Other References:
KOHEI KUGO ET AL.: "Synthesis and conformations of A-B-A tri-block copolymers with hydrophobic poly (g-benzyl L-glutamate) and hydrophilic poly (ethylene oxide)", POLYMER JOURNAL, vol. 19, no. 4, 1987, pages 375 - 381, XP002930756
YUKIHIRA HISAGO ET AL.: "Poly (beta-benzil-L-aspartate) wo fukumu ABA gata block kyoujugoutai no gousei to sono saibou secchakusei", KOUBUNSHI RONBUNSHU, vol. 42, no. 11, November 1985 (1985-11-01), pages 731 - 738, XP002945890
YUKIHIRA HISAGO ET AL.: "Poly (beta-benzil-L-aspartate) wo fukumu ABA gata block kyoujugoutai no gousei to sono saibou secchakusei", KOUBUNSHI RONBUNSHU, vol. 42, no. 11, November 1985 (1985-11-01), pages 731 - 738, XP002945890
Attorney, Agent or Firm:
Sakai, Hajime (Kojimachi 5-chome Chiyoda-ku Tokyo, JP)
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