Title:
POLYMERIZATION METHOD MEDIATED AND INITIATED BY OXYGEN-RESISTANT AND BIOCOMPATIBLE METALLIC TIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/241033
Kind Code:
A1
Abstract:
Disclosed in the present application are a polymerization method mediated and initiated by oxygen-resistant and biocompatible metallic tin and the use thereof. The polymerization method comprises: subjecting a pre-reaction mixed solution comprising a free radical polymerization monomer, a coordination agent and a solvent to a polymerization reaction confined between metallic tin and a substrate deposited with an initiator, thereby preparing a biocompatible polymer brush thin film. The polymerization method provided in the present application uses a metallic tin sheet/foil to mediate a surface initiated polymerization reaction, is simple, convenient and efficient, has high polymerization efficiency, requires no addition of any metal salt, requires no complex deoxygenization operation or inert environment, and can achieve large-scale preparation. Moreover, the method avoids the use of a copper catalyst, overcomes the defects of a high price, high toxicity, etc., caused by the use of metal copper and a copper salt as catalysts in existing atom transfer radical polymerization systems, and has huge application potential in the field of biomedicine.
Inventors:
ZHANG TAO (CN)
WU DAHENG (CN)
YIN XIAODONG (CN)
TAN RUNXIANG (CN)
WANG JIANING (CN)
WU DAHENG (CN)
YIN XIAODONG (CN)
TAN RUNXIANG (CN)
WANG JIANING (CN)
Application Number:
PCT/CN2023/071306
Publication Date:
December 21, 2023
Filing Date:
January 09, 2023
Export Citation:
Assignee:
NINGBO INSTITUTE OF MATERIALS TECH & ENGINEERING CHINESE ACADEMY OF SCIENCES (CN)
International Classes:
C08F292/00; C08F212/08; C08F220/14; C08F220/20; C08F220/28; C08F220/34; C08F220/38; C08F220/54; C08F226/06
Domestic Patent References:
| WO2015085268A1 | 2015-06-11 |
Foreign References:
| CN115010881A | 2022-09-06 | |||
| CN102952245A | 2013-03-06 |
Other References:
WU DAHENG, YIN XIAODONG, ZHAO YAQI, WANG YIWEN, LI DEKE, YANG FUCHAO, WANG LONG, CHEN YI, WANG JIANING, YANG HAOYONG, LIU XIAOLING: "Tinware-Inspired Aerobic Surface-Initiated Controlled Radical Polymerization (SI-Sn 0 CRP) for Biocompatible Surface Engineering", ACS MACRO LETTERS, vol. 12, no. 1, 17 January 2023 (2023-01-17), pages 71 - 76, XP093118631, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.2c00556
YIN XIAODONG, WU DAHENG, YANG HAOYONG, WANG JIANING, HUANG RUNHAO, ZHENG TIANYUE, SUN QI, CHEN TAO, WANG LIPING, ZHANG TAO: "Seawater-Boosting Surface-Initiated Atom Transfer Radical Polymerization for Functional Polymer Brush Engineering", ACS MACRO LETTERS, vol. 11, no. 5, 17 May 2022 (2022-05-17), pages 693 - 698, XP093118632, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.2c00138
YIN XIAODONG, WU DAHENG, YANG HAOYONG, WANG JIANING, HUANG RUNHAO, ZHENG TIANYUE, SUN QI, CHEN TAO, WANG LIPING, ZHANG TAO: "Seawater-Boosting Surface-Initiated Atom Transfer Radical Polymerization for Functional Polymer Brush Engineering", ACS MACRO LETTERS, vol. 11, no. 5, 17 May 2022 (2022-05-17), pages 693 - 698, XP093118632, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.2c00138
Attorney, Agent or Firm:
NANJING LI&FENG INTELLECTUAL PROPERTY AGENCY (SPECIAL GENERAL PARTNERSHIP) (CN)
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