Title:
POLYMORPH OF BRUTON'S TYROSINE KINASE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/048551
Kind Code:
A1
Abstract:
Provided are a polymorph of a Bruton's tyrosine kinase inhibitor, and a preparation method therefor and the use thereof, and specifically provided are two crystal forms of (R)-6-((1-acryloylpiperidin-3-yl)amino)-7-fluoro-4-((2-fluoro-4-morpholinophenyl)amino)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one, and a preparation method therefor and the use thereof. The two crystal forms have better stability, are less hygroscopic, have improved solubility and pharmacokinetic characteristics, and a stable preparation method, so that same can be mass-produced.
Inventors:
LI JINJING (CN)
JIANG TAOTAO (CN)
ZENG ZHENYA (CN)
YANG HAN (CN)
CHEN XI (CN)
JIANG TAOTAO (CN)
ZENG ZHENYA (CN)
YANG HAN (CN)
CHEN XI (CN)
Application Number:
PCT/CN2021/115856
Publication Date:
March 10, 2022
Filing Date:
September 01, 2021
Export Citation:
Assignee:
SHANGHAI HAIYAN PHARMACEUTICAL TECH CO LTD (CN)
YANGTZE RIVER PHARM GROUP CO (CN)
YANGTZE RIVER PHARM GROUP CO (CN)
International Classes:
C07D471/00; A61K31/437; A61P35/00
Domestic Patent References:
| WO2019062329A1 | 2019-04-04 | |||
| WO2020187267A1 | 2020-09-24 | |||
| WO2017128917A1 | 2017-08-03 |
Foreign References:
| CN102753548A | 2012-10-24 |
Attorney, Agent or Firm:
ADVANCE CHINA IP LAW OFFICE (CN)
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