Title:
POLYMORPH OF NUCLEOSIDE PHOSPHORAMIDATE PRODRUG AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2018/019188
Kind Code:
A1
Abstract:
Provided are a crystal form A of a nucleoside phosphoramidate prodrug as shown in formula I and a preparation method therefor. The crystal form A at least has an X-ray powder diffraction (XRPD) pattern with peaks at the 2θ angles of 6.9 ± 0.2°, 13.9 ± 0.2°, 20.8 ± 0.2° and 21.1 ± 0.2°. The crystal form A is stable in nature and suitable for being prepared into various dosage forms. The preparation method is simple in operation, and the prepared crystal form A is high in purity and low in industrialization costs.
Inventors:
YUAN JIANDONG (CN)
GU JIANING (CN)
HUANG YANGQING (CN)
MIAO LINFENG (CN)
LIANG CHAOHUA (CN)
SUN ZHANLI (CN)
GU JIANING (CN)
HUANG YANGQING (CN)
MIAO LINFENG (CN)
LIANG CHAOHUA (CN)
SUN ZHANLI (CN)
Application Number:
PCT/CN2017/093925
Publication Date:
February 01, 2018
Filing Date:
July 21, 2017
Export Citation:
Assignee:
BRIGHTGENE BIO-MEDICAL TECH CO LTD (CN)
International Classes:
C07H19/10; A61K31/7068; A61P35/00; C07H1/06
Domestic Patent References:
| WO2016055769A1 | 2016-04-14 | |||
| WO2015198058A1 | 2015-12-30 | |||
| WO2014076490A1 | 2014-05-22 |
Foreign References:
| CN106539810A | 2017-03-29 |
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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